Transcutaneous spinal cord stimulation on motor function in patients with spinal cord injury: A meta-analysis.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY NeuroRehabilitation Pub Date : 2024-01-01 DOI:10.3233/NRE-240057

Changpiao Shi, Yi Chen, Liang Ye, Jun Feng, Guoli Dong, Shangbo Lu

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Abstract

Background: It has been suggested that transcutaneous spinal cord stimulation (SCS) is effective in the rehabilitation of patients with spinal cord injury (SCI). However, the evidence is mainly based on case reports.

Objective: To summarize the influence of transcutaneous SCS on extremity motor function of patients with SCI in a meta-analysis.

Methods: A systematic literature search was performed in electronic databases including PubMed, Cochrane library, Embase, Web of Science, Wanfang, and CNKI to obtain relevant randomized controlled trials (RCTs). A random-effects model was used to pool the results by incorporating the impact of the potential heterogeneity. The most recent database search was conducted on December 31, 2023.

Results: Six small-scale open-label or single-blind RCTs were included. Transcutaneous SCS on the basis of conventional rehabilitation could significantly improve limb strength (mean difference: 4.82, p = 0.004; I2 = 0%) and attenuate spasticity (MD: -0.40, p = 0.02; I2 = 0%). The upper-extremity motor function was not significantly affected (p = 0.75). However, transcutaneous SCS significantly improved mobility as indicated by walking speed (MD: 0.13 m/s, p = 0.009; I2 = 0%) and walking distance (standardized MD: 0.62, I2 = 0%).

Conclusion: Transcutaneous SCS is effective in improving limb strength, spasticity and mobility of patients with SCI.

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经皮脊髓刺激对脊髓损伤患者运动功能的影响：荟萃分析。

背景：有人认为经皮脊髓刺激（SCS）对脊髓损伤（SCI）患者的康复有效。然而，这些证据主要基于病例报告：通过荟萃分析总结经皮脊髓刺激对 SCI 患者四肢运动功能的影响：在PubMed、Cochrane图书馆、Embase、Web of Science、万方和CNKI等电子数据库中进行了系统性文献检索，以获得相关的随机对照试验（RCT）。通过考虑潜在异质性的影响，采用随机效应模型对结果进行汇总。最新的数据库搜索于2023年12月31日进行：结果：共纳入六项小型开放标签或单盲 RCT。在传统康复基础上进行经皮 SCS 治疗可显著改善肢体力量（平均差：4.82，P = 0.004；I2 = 0%），减轻痉挛（MD：-0.40，P = 0.02；I2 = 0%）。上肢运动功能未受到明显影响（p = 0.75）。然而，经皮 SCS 显著改善了行走速度（MD：0.13 m/s，p = 0.009；I2 = 0%）和行走距离（标准化 MD：0.62，I2 = 0%）的活动能力：结论：经皮 SCS 可有效改善 SCI 患者的肢体力量、痉挛和活动能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.