The association of maternal smoking around birth with chronic respiratory diseases in adult offspring: A Mendelian randomization study.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Tobacco Induced Diseases Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI:10.18332/tid/189394

Xiao-Jun Wang, Yun-Xia Huo, Wei-Dong Hu, Chaoyan Yue

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Abstract

Introduction: Maternal smoking during pregnancy disturbs fetal lung development, and induces in their offspring childhood respiratory diseases. Whether it has a continued impact on offspring adult lung health and exerts a casual effect of chronic respiratory diseases (CRDs), remains uncertain. We seek to determine the causal relationships between maternal smoking around birth and offspring adult CRDs, using summary data from previously described cohorts.

Methods: Mendelian randomization (MR) study was used to analyze the genome-wide associations of maternal smoking around birth and offspring adult CRDs, including respiratory insufficiency, chronic obstructive pulmonary disease (COPD), related respiratory insufficiency, emphysema, COPD, COPD hospital admissions, early onset of COPD, later onset of COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer (LC), small cell lung carcinoma (SCLC), and lung squamous cell carcinoma (LUSC).

Results: After removing single-nucleotide polymorphisms (SNPs) associated with smoking by the offspring, maternal smoking around birth was associated with increased risk of offspring adult respiratory diseases (OR=1.14; 95% CI: 1.013-1.284; p=0.030), respiratory insufficiency (OR=2.413; 95% CI: 1.039-5.603; p=0.040), COPD (OR=1.14; 95% CI: 1.013-1.284; p=0.003), and asthma (OR=1.336; 95% CI: 1.161-1.538; p<0.001). Besides, maternal smoking during pregnancy was associated with a greater risk of LUSC (OR=1.229; 95% CI: 0.992-1.523; p=0.059) than the risk of IPF (OR=1.001; 95% CI: 0.999-1.003; p=0.224), LC (OR=1.203; 95% CI: 0.964-1.501; p=0.103), or SCLC (OR=1.11; 95% CI: 0.77-1.601; p=0.577).

Conclusions: In this MR analysis, maternal smoking around birth caused a strong risk factor for the offspring to develop lung problems and CRDs in adulthood. The policy related to smoking cessation for mothers during pregnancy should be encouraged.

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母亲出生前后吸烟与成年后代慢性呼吸道疾病的关系：孟德尔随机研究

简介母亲在怀孕期间吸烟会干扰胎儿的肺部发育，并诱发后代患上儿童呼吸系统疾病。至于母体吸烟是否会持续影响后代的成年肺部健康，并对慢性呼吸系统疾病（CRDs）产生偶然影响，目前仍不确定。我们试图利用之前描述的队列中的汇总数据，确定母亲在出生前后吸烟与后代成年后慢性呼吸道疾病之间的因果关系：方法：采用孟德尔随机化（MR）研究分析母亲在出生前后吸烟与后代成年 CRD（包括呼吸功能不全、慢性阻塞性肺病（COPD））之间的全基因组关联、相关的呼吸功能不全、肺气肿、慢性阻塞性肺病、慢性阻塞性肺病住院、慢性阻塞性肺病早发、慢性阻塞性肺病晚发、哮喘、特发性肺纤维化（IPF）、肺癌（LC）、小细胞肺癌（SCLC）和肺鳞癌（LUSC）。研究结果剔除与后代吸烟相关的单核苷酸多态性（SNPs）后，母亲在出生前后吸烟与后代罹患成人呼吸系统疾病的风险增加有关（OR=1.14；95% CI：1.013-1.284；p=0.030）、呼吸功能不全（OR=2.413；95% CI：1.039-5.603；p=0.040）、慢性阻塞性肺病（OR=1.14；95% CI：1.013-1.284；p=0.003）和哮喘（OR=1.336；95% CI：1.161-1.538；p结论：在这项磁共振分析中，母亲在分娩前后吸烟是导致后代成年后出现肺部问题和慢性阻塞性肺病的一个重要风险因素。应鼓励母亲在怀孕期间戒烟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.