Understanding nanoparticle-liver interactions in nanomedicine.

Expert opinion on drug delivery Pub Date : 2024-06-01 Epub Date: 2024-07-04 DOI:10.1080/17425247.2024.2375400

Yuxin He, Yifan Wang, Lin Wang, Wen Jiang, Stefan Wilhelm

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Abstract

Introduction: Understanding the interactions between administered nanoparticles and the liver is crucial for developing safe and effective nanomedicines. As the liver can sequester up to 99% of these particles due to its major phagocytic role, understanding these interactions is vital for clinical translation.

Areas covered: This review highlights recent studies on nanoparticle-liver interactions, including the influence of nanoparticle physicochemical properties on delivery, strategies to enhance delivery efficiency by modulating liver Kupffer cells, and their potential for treating certain hepatic diseases. Additionally, we discuss how aging impacts the liver's phagocytic functions.

Expert opinion: While liver accumulation can hinder nanomedicine safety and effectiveness, it also presents opportunities for treating certain liver diseases. A thorough understanding of nanoparticle-liver interactions is essential for advancing the clinical application of nanomedicines.

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了解纳米医学中纳米粒子与肝脏的相互作用。

导言：了解给药纳米粒子与肝脏之间的相互作用对于开发安全有效的纳米药物至关重要。由于肝脏具有主要的吞噬作用，可将多达 99% 的纳米颗粒封存起来，因此探索这些相互作用对于临床转化至关重要：本综述重点介绍了有关纳米粒子与肝脏相互作用的最新研究，包括纳米粒子的理化特性对递送的影响、通过调节肝脏库珀菲尔细胞提高递送效率的策略，以及它们治疗某些肝病的潜力。此外，报告还讨论了衰老如何影响肝脏的吞噬功能：虽然肝脏积聚会阻碍纳米药物的有效性，但它也为治疗肝病提供了机会，特别是考虑到衰老如何影响肝脏的吞噬功能。全面了解这些相互作用对于推进纳米药物的临床应用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Expert opinion on drug delivery

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