Noninvasive cardiac hemodynamics monitoring of acute myocardial ischemia in rats using near-infrared spectroscopy: A pilot study

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS Journal of Biophotonics Pub Date : 2024-06-27 DOI:10.1002/jbio.202300474
Sifan Chen, Qiao Li, Qinyu Pan, Qiuyan Yin, Liang Yue, Peng Zhang, Gong Chen, Weichao Liu
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Abstract

Noninvasive and real-time optical detection of cardiac hemodynamics dysfunction during myocardial ischemia remains challenging. In this study, we developed a near-infrared spectroscopy device to monitor rats' myocardial hemodynamics. The well-designed system can accurately reflect the hemodynamics changes by the classic upper limb ischemia test. Systemic hypoxia by disconnecting to the ventilator and cardiac ischemia by coronary artery slipknot ligation was conducted to monitor myocardial hemodynamics. When systemic hypoxia occurred, ΔHbR and ΔtHb increased significantly, whereas ΔHbO decreased rapidly. When coronary blood flow was obstructed by slipknots, cardiothoracic ΔHbO immediately begins to decline, while ΔHbR also significantly increases. Simultaneously, SpO2 did not show any obvious changes during myocardial ischemia, while SpO2 decreased significantly during systemic hypoxia. These results demonstrated that cardiothoracic hemodynamics stemmed from myocardial ischemia. This pilot study demonstrated the practicality of noninvasive, low-cost optical monitoring for cardiac oxygenation dysfunction in rats.

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利用近红外光谱对大鼠急性心肌缺血进行无创心脏血液动力学监测:试点研究。
对心肌缺血时心脏血流动力学功能障碍进行无创实时光学检测仍是一项挑战。在这项研究中,我们开发了一种近红外光谱仪来监测大鼠的心肌血流动力学。该系统设计合理,能准确反映经典的上肢缺血试验的血流动力学变化。通过断开呼吸机进行全身缺氧和冠状动脉滑结结扎进行心脏缺血来监测心肌血流动力学。当全身缺氧时,ΔHbR和ΔtHb显著升高,而ΔHbO迅速下降。当冠状动脉血流被滑结阻塞时,心胸ΔHbO 立即开始下降,而ΔHbR 也显著增加。同时,心肌缺血时 SpO2 没有明显变化,而全身缺氧时 SpO2 则明显下降。这些结果表明,心胸血流动力学源于心肌缺血。这项试验性研究证明了无创、低成本光学监测大鼠心脏氧合功能障碍的实用性。
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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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