Effects of Semaglutide in Doxorubicin-Induced Cardiac Toxicity in Wistar Albino Rats.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI:10.2147/CMAR.S468453

Raz Muhammed HamaSalih

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Abstract

Background: Doxorubicin (DOX) is used to treat various types of cancers. However, its use is restricted by cardiotoxicity, a leading cause of morbidity and mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) may be associated with cardioprotective properties.

Purpose: This study aims to determine the protective effects of different semaglutide (SEM) doses on DOX-induced cardiotoxicity in a rat model.

Methodology: Thirty-five female Wistar rats were divided into five groups. The first group received distilled water as a negative control (NC); the positive control (PC) group received distilled water plus DOX; the third group (SL) received a low dose of SEM (0.06 mg/kg) plus DOX; the fourth group (SM) received a moderate dose of SEM (0.12 mg/kg) plus DOX; and the fifth group (SH) received a high dose of SEM (0.24 mg/kg) plus DOX. Blood samples were collected on day 8 to assess serum troponin, lactate dehydrogenase (LDH), creatine phosphokinase (CPK), total lipid profile, and vascular cell adhesion molecule 1 (VCAM-1). Cardiac tissue was sent for histopathological analysis.

Results: DOX increased the total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), LDH, and CKP levels. Moderate and high doses of semaglutide significantly reduced serum cholesterol levels (*p = 0.0199), (**p = 0.0077), respectively. A significant reduction (***p = 0.0013) in total body weight after treatment with SEM was observed in the SL group and a highly significant reduction (****p < 0.0001) was observed in the SM and SH groups. SEM at all doses reduced CPK levels. The SL group showed a significant reduction in troponin level (*p=0.0344). Serum LDH levels were reduced by all three SEM doses. The histopathological findings support the biochemical results.

Conclusion: Semaglutide may possess cardioprotective properties against DOX-induced cardiotoxicity in a rat model by decreasing serum biochemical markers of cardiotoxicity.

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塞马鲁肽对Wistar白化大鼠多柔比星诱发的心脏毒性的影响

背景：多柔比星（DOX多柔比星（DOX）用于治疗各种癌症。然而，其使用受到心脏毒性的限制，而心脏毒性是发病和死亡的主要原因。目的：本研究旨在确定不同剂量的塞马鲁肽（SEM）对大鼠模型中 DOX 诱导的心脏毒性的保护作用：将 35 只雌性 Wistar 大鼠分为 5 组。第一组接受蒸馏水作为阴性对照（NC）；阳性对照（PC）组接受蒸馏水加 DOX；第三组（SL）接受低剂量 SEM（0.06 mg/kg）加 DOX；第四组（SM）接受中等剂量 SEM（0.12 mg/kg）加 DOX；第五组（SH）接受高剂量 SEM（0.24 mg/kg）加 DOX。第8天采集血样，评估血清肌钙蛋白、乳酸脱氢酶（LDH）、肌酸磷酸激酶（CPK）、总脂质和血管细胞粘附分子1（VCAM-1）。心脏组织被送去进行组织病理学分析：结果：DOX增加了总胆固醇（TC）、低密度脂蛋白（LDL）、甘油三酯（TG）、LDH和CKP水平。中等剂量和高剂量的塞马鲁肽分别显著降低了血清胆固醇水平（*p = 0.0199）和（**p = 0.0077）。使用 SEM 治疗后，SL 组的总重量明显降低（***p = 0.0013），SM 组和 SH 组的总重量也有非常明显的降低（****p < 0.0001）。所有剂量的 SEM 都能降低 CPK 水平。SL组的肌钙蛋白水平明显下降（*p=0.0344）。三种剂量的 SEM 均降低了血清 LDH 水平。组织病理学结果支持生化结果：结论：在大鼠模型中，塞马鲁肽可通过降低血清中心脏毒性的生化指标，对DOX诱导的心脏毒性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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