Beyond Meta-Omics: Functional Genomics in Future Marine Microbiome Research.

IF 14.3 1区 地球科学 Q1 GEOCHEMISTRY & GEOPHYSICS Annual Review of Marine Science Pub Date : 2024-07-01 DOI:10.1146/annurev-marine-020123-100931
Yin Chen
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Abstract

When President Bill Clinton and Francis Collins, then the director of the National Human Genome Research Institute, celebrated the near completion of the human genome sequence at the White House in the summer of 2000, it is unlikely that they or anyone else could have predicted the blossoming of meta-omics in the following two decades and their applications in modern human microbiome and environmental microbiome research. This transformation was enabled by the development of high-throughput sequencing technologies and sophisticated computational biology tools and bioinformatics software packages. Today, environmental meta-omics has undoubtedly revolutionized our understanding of ocean ecosystems, providing the genetic blueprint of oceanic microscopic organisms. In this review, I discuss the importance of functional genomics in future marine microbiome research and advocate a position for a gene-centric, bottom-up approach in modern oceanography. I propose that a synthesis of multidimensional approaches is required for a better understanding of the true functionality of the marine microbiome.

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超越元微生物学:未来海洋微生物组研究中的功能基因组学。
2000 年夏天,当比尔-克林顿总统和时任美国国家人类基因组研究所所长的弗朗西斯-柯林斯在白宫庆祝人类基因组序列即将完成时,他们或其他任何人都不可能预料到元组学在随后二十年的蓬勃发展及其在现代人类微生物组和环境微生物组研究中的应用。这一转变得益于高通量测序技术、先进的计算生物学工具和生物信息学软件包的发展。如今,环境元组学无疑彻底改变了我们对海洋生态系统的认识,提供了海洋微观生物的遗传蓝图。在这篇综述中,我讨论了功能基因组学在未来海洋微生物组研究中的重要性,并主张在现代海洋学中采用以基因为中心、自下而上的方法。我建议,为了更好地了解海洋微生物组的真正功能,需要综合采用多维方法。
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来源期刊
Annual Review of Marine Science
Annual Review of Marine Science 地学-地球化学与地球物理
CiteScore
33.60
自引率
0.60%
发文量
40
期刊介绍: The Annual Review of Marine Science, published since 2009, offers a comprehensive overview of the field. It covers various disciplines, including coastal and blue water oceanography (biological, chemical, geological, and physical), ecology, conservation, and technological advancements related to the marine environment. The journal's transition from gated to open access through Annual Reviews' Subscribe to Open program ensures that all articles are available under a CC BY license, promoting wider accessibility and dissemination of knowledge.
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