{"title":"Biogenic synthesis of silver nanoparticles from the leaf extract of Erythroxylum Monogynum Roxb: Evaluation of antibacterial and anticancer effects","authors":"Dhanunjaya Kumar Chadive , Priyanka Gurrala , Muralidhara Rao Dowlathabad","doi":"10.1016/j.nanoso.2024.101222","DOIUrl":null,"url":null,"abstract":"<div><p>This study demonstrates an approach for the green synthesis of silver nanoparticles (AgNPs) using leaf extracts from <em>Erythroxylum</em> monogynum Roxb. The leaf extracts have the dual function include the reduction of the silver nitrate and stabilizing the AgNPs. These AgNPs were characterized using UV-Vis spectroscopy, X-ray diffraction, and other analytical methods. This study showed that the AgNPs had a distinct crystalline structure, with particle sizes varying from ~20–60 nm with a noticeable absorbance peak at 460 nm, which confirms the synthesis of AgNPs. Later <em>in-vitro</em> based biological effects were evaluated, where demonstrated substantial antibacterial activity against pathogenic strains of <em>Pseudomonas aeruginosa</em> and <em>Escherichia coli</em>, suggesting their potential effectiveness in treating microbial diseases. In addition, further study examined the inhibitory effect of the AgNPs on the proliferation of cancer cells, resulting significant level of inhibition when tested on CaCO2 and HELA cancer cell lines. Based on the obtained results we concluded the potential of these AgNPs as a promising therapeutic agent in microbial infections and cancers.</p></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":null,"pages":null},"PeriodicalIF":5.4500,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X24001331","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 0
Abstract
This study demonstrates an approach for the green synthesis of silver nanoparticles (AgNPs) using leaf extracts from Erythroxylum monogynum Roxb. The leaf extracts have the dual function include the reduction of the silver nitrate and stabilizing the AgNPs. These AgNPs were characterized using UV-Vis spectroscopy, X-ray diffraction, and other analytical methods. This study showed that the AgNPs had a distinct crystalline structure, with particle sizes varying from ~20–60 nm with a noticeable absorbance peak at 460 nm, which confirms the synthesis of AgNPs. Later in-vitro based biological effects were evaluated, where demonstrated substantial antibacterial activity against pathogenic strains of Pseudomonas aeruginosa and Escherichia coli, suggesting their potential effectiveness in treating microbial diseases. In addition, further study examined the inhibitory effect of the AgNPs on the proliferation of cancer cells, resulting significant level of inhibition when tested on CaCO2 and HELA cancer cell lines. Based on the obtained results we concluded the potential of these AgNPs as a promising therapeutic agent in microbial infections and cancers.
期刊介绍:
Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .