José Jaime Martínez-Magaña , Jorge Hurtado-Soriano , Nadia Alejandra Rivero-Segura , Janitza L. Montalvo-Ortiz , Paola Garcia-delaTorre , Kristhian Becerril-Rojas , Juan Carlos Gomez-Verjan
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引用次数: 0
Abstract
Health problems associated with aging are a major public health concern for the future. Aging is a complex process with wide intervariability among individuals. Therefore, there is a need for innovative public health strategies that target factors associated with aging and the development of tools to assess the effectiveness of these strategies accurately. Novel approaches to measure biological age, such as epigenetic clocks, have become relevant. These clocks use non-sequential variable information from the genome and employ mathematical algorithms to estimate biological age based on DNA methylation levels. Therefore, in the present study, we comprehensively review the current status of the epigenetic clocks and their associations across the human phenome. We emphasize the potential utility of these tools in an epidemiological context, particularly in evaluating the impact of public health interventions focused on promoting healthy aging. Our review describes associations between epigenetic clocks and multiple traits across the life and health span. Additionally, we highlighted the evolution of studies beyond mere associations to establish causal mechanisms between epigenetic age and disease. We explored the application of epigenetic clocks to measure the efficacy of interventions focusing on rejuvenation.
与老龄化相关的健康问题是未来公共卫生的主要关注点。老龄化是一个复杂的过程,个体之间存在广泛的可变性。因此,有必要针对与衰老相关的因素制定创新的公共卫生战略,并开发工具来准确评估这些战略的有效性。测量生物年龄的新方法(如表观遗传时钟)已变得十分重要。这些时钟利用基因组中的非序列变量信息,采用数学算法,根据 DNA 甲基化水平估算生物年龄。因此,在本研究中,我们全面回顾了表观遗传时钟的现状及其在人类表型组中的关联。我们强调了这些工具在流行病学方面的潜在用途,特别是在评估以促进健康老龄化为重点的公共卫生干预措施的影响方面。我们的综述描述了表观遗传时钟与生命和健康跨度中多种特征之间的关联。此外,我们还强调了研究的演变,即从单纯的关联到建立表观遗传年龄与疾病之间的因果机制。我们探讨了如何应用表观遗传时钟来衡量以返老还童为重点的干预措施的效果。
期刊介绍:
Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.