Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics: X Pub Date : 2024-06-26 DOI:10.1016/j.ijpx.2024.100265
Vahid Tayebi-Khorrami , Pouria Rahmanian-Devin , Mohammad Reza Fadaei , Jebraeel Movaffagh , Vahid Reza Askari
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Abstract

Cancer remains a major global health challenge, and despite available treatments, its prognosis remains poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These nanofibers exhibit remarkable capabilities in targeted and controlled drug release. Their inherent characteristics, such as a high surface area-to-volume ratio, make them attractive candidates for drug delivery applications. Smart nanofibers can release drugs in response to specific stimuli, including pH, temperature, magnetic fields, and light. This unique feature not only reduces side effects but also enhances the overall efficiency of drug delivery systems. Electrospinning, a widely used method, allows the precision fabrication of smart nanofibers. Its advantages include high efficiency, user-friendliness, and the ability to control various manufacturing parameters. In this review, we explore the latest developments in producing smart electrospun nanofibers for cancer treatment. Additionally, we discuss the materials used in manufacturing these nanofibers and the critical parameters involved in the electrospinning process.

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智能电纺纳米纤维在癌症治疗中的先进应用:深入了解材料性能和电纺参数
癌症仍然是全球健康面临的一大挑战,尽管有各种治疗方法,但预后仍然很差。最近,研究人员将注意力转向了用于癌症药物输送的智能纳米纤维。这些纳米纤维在靶向和可控药物释放方面表现出卓越的能力。它们的固有特性,如高表面积体积比,使其成为药物输送应用的理想候选材料。智能纳米纤维可根据特定刺激释放药物,包括 pH 值、温度、磁场和光。这一独特功能不仅能减少副作用,还能提高给药系统的整体效率。电纺丝是一种广泛使用的方法,可精确制造智能纳米纤维。它的优点包括效率高、使用方便以及能够控制各种制造参数。在本综述中,我们将探讨生产用于癌症治疗的智能电纺纳米纤维的最新进展。此外,我们还讨论了用于制造这些纳米纤维的材料以及电纺过程中涉及的关键参数。
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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
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