Dual-responsive, highly bacteriostatic and swellable chitosan-based hydrogels loaded with 5-fluorouracil for sustainable release

Abstract

In this work, a dual-responsive hydrogel for sustainable release of drug was prepared using chitosan grafted with PBA as substrate to form semi-interpenetrating polymer networks (S-IPN) via free-radical crosslinking polymerization of acrylic acid in the presence of MBAA as a crosslinker and KPS as an initiator as well as Fe³⁺.ions introduced. The results from comprehensive characterization indicated that the as-prepared hydrogel possesses cavity structure with the pores of varying sizes, thus facilitating the accommodation of 5-fluorouracil as a model drug. In addition, the swelling behavior of the hydrogels in different pH buffers and glucose solutions was also investigated. As expected, the prepared hydrogels are pH and glucose responsive due to PAA and phenylboronic acid incorporated into the hydrogel, which enables the slow or sustainable release of drug. Moreover, the release processes were fitted with various kinetic models whereas the release was better described by Korsmeyer-Peppas model or the drug release is mainly governed by the release mechanism of the hydrogel is primarily driven by Fickian diffusion from a mechanical point of view. Hydrogel loaded with drug was found to have good antibacterial effects against E. coli and S. aureus, leading to the potential for various medical-related applications.