Emergence of Lumpy Skin Disease Virus Infection in Yaks, Cattle-Yaks, and Cattle on the Qinghai–Xizang Plateau of China

IF 3.5 2区农林科学 Q2 INFECTIOUS DISEASES Transboundary and Emerging Diseases Pub Date : 2024-07-01 DOI:10.1155/2024/2383886

Yuqing Song, Ou Zuo, Gelin Zhang, Jianwu Hu, Zhancheng Tian, Guiquan Guan, Jianxun Luo, Hong Yin, Youjun Shang, Junzheng Du

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Abstract

Lumpy skin disease (LSD) is a viral disease caused by lumpy skin disease virus (LSDV), which mainly infects cattle and can cause huge economic losses. In May 2023, yaks, cattle-yaks, and cattle in Tibet (Xizang), China, developed fever, skin nodules, and severe discharges and were suspected to be cases of LSD. Samples from these animals were analyzed using molecular biology and serological methods. The RPO30, P32, and GPCR genes were amplified by PCR and sequenced, and the whole genome of the virus was determined using viral metagenomics technology. Sequencing results showed that it was indeed an LSDV infection, and enzyme-linked immunosorbent assay results confirmed the presence of LSDV antibodies. The whole genome phylogenetic tree shows that LSDV/CHINA/Tibet/2023 is different from the previous epidemic strains in China, but clusters with India 2022 strain. This is the first report of LSD in yaks, cattle-yaks, and cattle on the highest altitude plateau in the world.

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中国青藏高原牦牛、牛羊和牛中出现的瘤胃病毒感染现象

块皮病（LSD）是由块皮病病毒（LSDV）引起的一种病毒性疾病，主要感染牛，可造成巨大的经济损失。2023 年 5 月，中国西藏（西藏）的牦牛、黄牛和黄牛出现发热、皮肤结节和严重分泌物，疑似 LSD 病例。采用分子生物学和血清学方法对这些动物的样本进行了分析。通过 PCR 扩增了 RPO30、P32 和 GPCR 基因并进行了测序，利用病毒元组学技术确定了病毒的全基因组。测序结果表明这确实是一种 LSDV 感染，酶联免疫吸附试验结果证实了 LSDV 抗体的存在。全基因组系统进化树显示，LSDV/CHINA/Tibet/2023与之前在中国流行的毒株不同，但与印度2022毒株聚类。这是世界上首次报道在海拔最高的高原地区的牦牛、牛羊和牛中发现 LSD 病毒。

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.