Data on clozapine-induced agranulocytosis suggest monitoring could be relaxed

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Abstract

A nationwide cohort study conducted in Finland has found that risk of clozapine-induced agranulocytosis, while greater than that associated with other antipsychotics, decreases considerably with longer-term use of the medication. The study's findings lend support to the idea that hematological monitoring requirements for patients receiving clozapine could be relaxed over time, the investigators stated. Study results were published online April 29, 2024, in Lancet Psychiatry.

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有关氯氮平诱发粒细胞减少症的数据表明,可以放松监测
芬兰进行的一项全国性队列研究发现,氯氮平诱发粒细胞减少症的风险虽然高于其他抗精神病药物,但随着用药时间的延长会大大降低。研究人员表示,这项研究结果支持了一种观点,即随着时间的推移,可以放宽对接受氯氮平治疗的患者的血液监测要求。研究结果于2024年4月29日在线发表在《柳叶刀精神病学》上。
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