Just over a year ago, I somewhat reluctantly weighed in on the implications for psychiatry of the resurgent interest in psychedelic drugs (Price, 2024). In contrast to the “psychedelic era” of the 1960s and 1970s, this time public interest in these compounds has been accompanied by skillful politico-legal advocacy and systematic research. Both of those endeavors require high levels of funding, and both private philanthropic and for-profit pharmaceutical entities have, for better or worse, stepped in.
{"title":"Psychedelics and psychosis: Quantifying the risk","authors":"Lawrence H. Price M.D.","doi":"10.1002/pu.31278","DOIUrl":"https://doi.org/10.1002/pu.31278","url":null,"abstract":"<p>Just over a year ago, I somewhat reluctantly weighed in on the implications for psychiatry of the resurgent interest in psychedelic drugs (Price, 2024). In contrast to the “psychedelic era” of the 1960s and 1970s, this time public interest in these compounds has been accompanied by skillful politico-legal advocacy and systematic research. Both of those endeavors require high levels of funding, and both private philanthropic and for-profit pharmaceutical entities have, for better or worse, stepped in.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Use of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide was associated with reduced risk of alcohol-related hospitalization in patients with alcohol use disorder (AUD), a cohort study has found. Both semaglutide and the GLP-1 receptor agonist liraglutide were associated with lower risk of hospitalization than use of medication treatments for AUD. Study results were published online Nov. 13, 2024, in JAMA Psychiatry.
{"title":"Weight-loss drugs improve outcomes in patients with alcohol use disorder","authors":"","doi":"10.1002/pu.31274","DOIUrl":"https://doi.org/10.1002/pu.31274","url":null,"abstract":"<p>Use of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide was associated with reduced risk of alcohol-related hospitalization in patients with alcohol use disorder (AUD), a cohort study has found. Both semaglutide and the GLP-1 receptor agonist liraglutide were associated with lower risk of hospitalization than use of medication treatments for AUD. Study results were published online Nov. 13, 2024, in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta-analysis suggests safety of methylphenidate, atomoxetine in pregnancy","authors":"","doi":"10.1002/pu.31279","DOIUrl":"https://doi.org/10.1002/pu.31279","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Individuals who had an emergency department (ED) visit related to use of psychedelic drugs were at higher risk of developing a psychotic disorder than those in the general population, a retrospective cohort study has found. These individuals also were more likely to develop a schizophrenia spectrum disorder compared with those who had an ED visit involving alcohol or cannabis, the researchers reported. Study results were published online Nov. 13, 2024, in JAMA Psychiatry.
{"title":"ED visit for psychedelic use confers increased risk of psychosis","authors":"","doi":"10.1002/pu.31273","DOIUrl":"https://doi.org/10.1002/pu.31273","url":null,"abstract":"<p>Individuals who had an emergency department (ED) visit related to use of psychedelic drugs were at higher risk of developing a psychotic disorder than those in the general population, a retrospective cohort study has found. These individuals also were more likely to develop a schizophrenia spectrum disorder compared with those who had an ED visit involving alcohol or cannabis, the researchers reported. Study results were published online Nov. 13, 2024, in <i>JAMA Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A placebo-controlled study has found that use of omega-3 fatty acids had no protective effect on transition to psychosis in high-risk young people aged 13 to 20. This is the third recent randomized controlled trial (RCT) that has failed to replicate results of a 12-week trial that found a lower transition rate to psychosis in young people receiving omega-3s.
{"title":"No protective effect of omega-3s for youths at risk of psychosis","authors":"","doi":"10.1002/pu.31277","DOIUrl":"https://doi.org/10.1002/pu.31277","url":null,"abstract":"<p>A placebo-controlled study has found that use of omega-3 fatty acids had no protective effect on transition to psychosis in high-risk young people aged 13 to 20. This is the third recent randomized controlled trial (RCT) that has failed to replicate results of a 12-week trial that found a lower transition rate to psychosis in young people receiving omega-3s.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several sensitivity analyses of a Phase 3b trial have demonstrated that esketamine nasal spray was consistently more efficacious than extended-release quetiapine in patients with treatment-resistant depression (TRD). The additional analyses of the ESCAPE-TRD trial used multiple thresholds for remission and relapse. Study results were published online Dec. 2, 2024, in The British Journal of Psychiatry.
{"title":"Analysis of trial confirms efficacy of esketamine nasal spray in TRD","authors":"","doi":"10.1002/pu.31276","DOIUrl":"https://doi.org/10.1002/pu.31276","url":null,"abstract":"<p>Several sensitivity analyses of a Phase 3b trial have demonstrated that esketamine nasal spray was consistently more efficacious than extended-release quetiapine in patients with treatment-resistant depression (TRD). The additional analyses of the ESCAPE-TRD trial used multiple thresholds for remission and relapse. Study results were published online Dec. 2, 2024, in <i>The British Journal of Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trial finds fezolinetant efficacious for vasomotor symptoms in menopause","authors":"","doi":"10.1002/pu.31282","DOIUrl":"https://doi.org/10.1002/pu.31282","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta-analysis finds viloxazine effective for youths with ADHD","authors":"","doi":"10.1002/pu.31281","DOIUrl":"https://doi.org/10.1002/pu.31281","url":null,"abstract":"","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 3","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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