{"title":"Bioactive Phenylpropanoid Glycosides, Dimers, and Heterodimers from the Bark of Cinnamomum cassia (L.) J.Presl","authors":"Hongxia Fan, Gengfeng Huang, Qi Guo, Jiahui Ma, Yujing Huang, Shangxiong Huang, Meiwen Wei, Caihong Xie, Bingbing Yan, Suqing Zhao, Guodong Chen, Junxia Zheng, Zhengqun Zhou, Hao Gao","doi":"10.1021/acs.jafc.4c02129","DOIUrl":null,"url":null,"abstract":"Six new phenylpropanoid glycosides (<b>1</b>–<b>6</b>), two new phenylethanol glycosides (<b>7</b> and <b>8</b>), one new phenylmethanol glycoside (<b>9</b>), three new phenylpropanoid dimers (<b>10</b>–<b>12</b>), two new phenylpropanoid–flavan-3-ol heterodimers (<b>13</b> and <b>14</b>), and six known relevant compounds (<b>15</b>–<b>20</b>) were isolated and identified from the well-liked edible and medicinal substance (the bark of <i>Cinnamomum cassia</i> (L.) J.Presl). The structures of these isolates were determined by using spectroscopic analyses, chemical methods, and quantum chemical calculations. Notably, compounds <b>4</b>–<b>9</b> were rare apiuronyl-containing glycosides, and compounds <b>13</b> and <b>14</b> were heterodimers of phenylpropanoids and flavan-3-ols linked through C-9″–C-8 bonds. The antioxidant and α-glucosidase inhibitory activities of all isolates were evaluated. Compounds <b>10</b> and <b>12</b> exhibited DPPH radical scavenging capacities with IC<sub>50</sub> values of 20.1 and 13.0 μM, respectively (vitamin C IC<sub>50</sub> value of 14.3 μM). In the ORAC experiment, all these compounds exhibited different levels of capacity for scavenging free radicals, and compound <b>10</b> displayed extraordinary free radical scavenging capacity with the ORAC value of 6.42 ± 0.01 μM TE/μM (EGCG ORAC value of 1.54 ± 0.02 μM TE/μM). Compound <b>12</b> also showed significant α-glucosidase inhibitory activity with an IC<sub>50</sub> of 56.3 μM (acarbose IC<sub>50</sub> of 519.4 μM).","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1021/acs.jafc.4c02129","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Six new phenylpropanoid glycosides (1–6), two new phenylethanol glycosides (7 and 8), one new phenylmethanol glycoside (9), three new phenylpropanoid dimers (10–12), two new phenylpropanoid–flavan-3-ol heterodimers (13 and 14), and six known relevant compounds (15–20) were isolated and identified from the well-liked edible and medicinal substance (the bark of Cinnamomum cassia (L.) J.Presl). The structures of these isolates were determined by using spectroscopic analyses, chemical methods, and quantum chemical calculations. Notably, compounds 4–9 were rare apiuronyl-containing glycosides, and compounds 13 and 14 were heterodimers of phenylpropanoids and flavan-3-ols linked through C-9″–C-8 bonds. The antioxidant and α-glucosidase inhibitory activities of all isolates were evaluated. Compounds 10 and 12 exhibited DPPH radical scavenging capacities with IC50 values of 20.1 and 13.0 μM, respectively (vitamin C IC50 value of 14.3 μM). In the ORAC experiment, all these compounds exhibited different levels of capacity for scavenging free radicals, and compound 10 displayed extraordinary free radical scavenging capacity with the ORAC value of 6.42 ± 0.01 μM TE/μM (EGCG ORAC value of 1.54 ± 0.02 μM TE/μM). Compound 12 also showed significant α-glucosidase inhibitory activity with an IC50 of 56.3 μM (acarbose IC50 of 519.4 μM).
期刊介绍:
The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.