Molecular Mechanisms Underlying the Therapeutic Potential of Plant-Based α-Amylase Inhibitors for Hyperglycemic Control in Diabetes.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-07-02 DOI:10.2174/0115733998304373240611110224
Amritpal Kaur, Shareen Singh, Somdutt Mujwar, Thakur Gurjeet Singh
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Abstract

Background: Diabetes mellitus (DM), arising from pancreatic β-cell dysfunction and disrupted alpha-amylase secretion, manifests as hyperglycemia. Synthetic inhibitors of alphaamylase like acarbose manage glucose but pose adverse effects, prompting interest in plantderived alternatives rich in antioxidants and anti-inflammatory properties.

Objective: The current review investigates plant-based alpha-amylase inhibitors, exploring their potential therapeutic roles in managing DM. Focusing on their ability to modulate postprandial hyperglycemia by regulating alpha-amylase secretion, it assesses their efficacy, health benefits, and implications for diabetes treatment.

Method: This review examines plant-derived alpha-amylase inhibitors as prospective diabetic mellitus treatments using PubMed, Google Scholar, and Scopus data.

Results: Plant-derived inhibitors, including A. deliciosa, B. egyptiaca, and N. nucifera, exhibit anti-inflammatory and antioxidant properties, effectively reducing alpha-amylase levels in diabetic conditions. Such alpha-amylase inhibitors showed promising alternative treatment in managing diabetes with reduced adverse effects.

Conclusion: The current literature concludes that plant-derived alpha-amylase inhibitors present viable therapeutic avenues for diabetes management by modulating alpha-amylase secretion by regulating inflammatory, oxidative stress, and apoptotic mechanisms involved in the pathogenesis of diabetes. Further investigation into their formulations and clinical efficacy may reveal their more comprehensive diabetes therapeutic significance, emphasizing their potential impact on glucose regulation and overall health.

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植物性α-淀粉酶抑制剂控制糖尿病患者高血糖治疗潜力的分子机制。
背景:糖尿病(DM)由胰腺β细胞功能障碍和α-淀粉酶分泌紊乱引起,表现为高血糖。阿卡波糖等α-淀粉酶合成抑制剂可控制血糖,但会带来不良影响,这促使人们对富含抗氧化剂和抗炎特性的植物替代品产生兴趣:本综述研究了植物性α-淀粉酶抑制剂,探讨了它们在控制糖尿病方面的潜在治疗作用。重点关注它们通过调节α-淀粉酶分泌来调节餐后高血糖的能力,评估它们的功效、对健康的益处以及对糖尿病治疗的影响:本综述利用 PubMed、Google Scholar 和 Scopus 数据研究了植物提取的α-淀粉酶抑制剂作为糖尿病治疗的前瞻性方法:结果:植物α-淀粉酶抑制剂(包括A. deliciosa、B. egyptiaca和N. nucifera)具有抗炎和抗氧化特性,能有效降低糖尿病患者体内的α-淀粉酶水平。这些α-淀粉酶抑制剂是治疗糖尿病的有前途的替代疗法,并能减少不良反应:现有文献得出结论,植物提取的α-淀粉酶抑制剂通过调节糖尿病发病机制中涉及的炎症、氧化应激和细胞凋亡机制来调节α-淀粉酶的分泌,为糖尿病治疗提供了可行的治疗途径。对其配方和临床疗效的进一步研究可能会揭示其更全面的糖尿病治疗意义,强调其对血糖调节和整体健康的潜在影响。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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