Profile and Prognostic Impact of Multimorbidity in Elderly Patients with Heart Failure: Are there Differences between Men and Women?

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-07-03 DOI:10.1007/s11897-024-00673-x
Rocío Del Pilar Falcón Fleytas, Osmar Antonio Centurión, Javier Galeano Figueredo, Hugo González Saldivar, Jorge E Martínez
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Abstract

Purpose of review: Heart failure (HF) represents a pathology in constant growth, but, despite the fact that a significant proportion of its population is comprised of elderly patients, they are not adequately represented in clinical trials or registries. They constitute a heterogeneous population with their particularities and interaction of the multiple comorbidities that characterize this age group, which makes the clinical course, prognosis and outcomes of the disease different.

Recent findings: Compared to men, women with HF tend to be older, with a greater burden of non-cardiovascular comorbidities, less ischemic heart disease and preserved ventricular function in most cases. This fact translates into worse self-perceived quality of life, with lower hospitalization and mortality rates. Moreover, paradoxically, women are less likely to receive treatment recommended by clinical practice guidelines, including revascularization and device placement. As there are not enough representative studies of this population, the reasons for these results with better prognosis and relatively benign impact in the elderly female population are unknown, which is why it is necessary to continue with research in order to obtain greater evidence of the exposed gaps.

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老年心力衰竭患者的多病特征和预后影响:男女之间是否存在差异?
综述目的:心力衰竭(HF)是一种不断发展的病理现象,尽管老年患者在心力衰竭患者中所占比例很大,但在临床试验或登记中却没有得到充分的体现。老年心力衰竭患者是一个异质性群体,他们有自己的特点,而且这个年龄段的患者有多种并发症,这使得疾病的临床过程、预后和治疗效果都不尽相同:与男性相比,患有心房颤动的女性往往年龄较大,非心血管并发症较多,缺血性心脏病较少,心室功能在大多数情况下得以保留。这一事实导致患者的自我感觉生活质量较差,住院率和死亡率较低。此外,矛盾的是,女性接受临床实践指南推荐的治疗(包括血管重建和装置植入)的可能性较低。由于对这一人群的代表性研究还不够多,这些结果在老年女性人群中具有更好的预后和相对良性影响的原因尚不清楚,这就是为什么有必要继续开展研究,以便获得更多证据来证明暴露出的差距。
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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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