The Potential Mechanisms Behind Adverse Effect of Coronavirus Disease-19 on Heart and Liver Damage: A Review.

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES Ethiopian Journal of Health Sciences Pub Date : 2024-01-01 DOI:10.4314/ejhs.v34i1.10
Tolessa Muleta Daba, Mulatu Mokonon, Elsa Niguse, Meron Getahun
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Abstract

Background: Coronaviruses (CoVs) belong to the RNA viruses family. The viruses in this family are known to cause mild respiratory disease in humans. The origin of the novel SARS-COV2 virus that caused the coronavirus-19 disease (COVID-19) is the Wuhan city in China from where it disseminated to cause a global pandemic. Although lungs are the predominant target organ for Coronavirus Disease-19 (COVID-19), since its outbreak, the disease is known to affect heart, blood vessels, kidney, intestine, liver and brain. This review aimed to summarize the catastrophic impacts of Coronavirus disease-19 on heart and liver along with its mechanisms of pathogenesis.

Methods: The information used in this review was obtained from relevant articles published on PubMed, Google Scholar, Google, WHO website, CDC and other sources. Key searching statements and phrases related to COVID-19 were used to retrieve information. Original research articles, review papers, research letters and case reports were used as a source of information.

Results: Besides causing severe lung injury, COVID-19 has also been reported to affect and cause dysfunction of many other organs. COVID-19 infection can affect people by downregulating membrane-bound active angiotensin-converting enzyme (ACE). People who have deficient ACE2 expression are more vulnerable to COVID-19 infection. The patients' pre-existing co-morbidities are major risk factors that predispose individuals to severe COVID-19.

Conclusion: The disease severity and its broad spectrum phenotype is a result of combined direct and indirect pathogenic factors. Therefore, protocols that harmonize many therapeutic preferences should be the best alternatives to de-escalate the disease and obviate deaths caused as a result of multiple organ damage and dysfunction induced by the disease.

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Coronavirus Disease-19 对心脏和肝脏损伤产生不良影响的潜在机制:综述。
背景:冠状病毒(CoV冠状病毒(CoV)属于 RNA 病毒科。已知冠状病毒可引起人类轻微的呼吸道疾病。引起冠状病毒-19 疾病(COVID-19)的新型 SARS-COV2 病毒的原产地是中国武汉市,它从那里传播并引起全球大流行。尽管肺部是冠状病毒-19(COVID-19)的主要靶器官,但自其爆发以来,已知该疾病会影响心脏、血管、肾脏、肠道、肝脏和大脑。本综述旨在总结冠状病毒疾病-19对心脏和肝脏的灾难性影响及其发病机制:本综述所使用的信息来自 PubMed、Google Scholar、Google、WHO 网站、CDC 及其他来源发表的相关文章。使用与 COVID-19 相关的关键搜索语句和短语来检索信息。原始研究文章、综述论文、研究信函和病例报告被用作信息来源:结果:COVID-19 除了会造成严重的肺损伤外,还有报道称它还会影响许多其他器官并导致其功能障碍。COVID-19 感染可通过下调膜结合活性血管紧张素转换酶(ACE)来影响人体。ACE2 表达不足的人更容易感染 COVID-19。患者原有的并发症是导致其感染严重的 COVID-19 的主要风险因素:结论:疾病的严重程度及其广谱表型是直接和间接致病因素共同作用的结果。因此,协调多种治疗偏好的方案应是缓解病情、避免因疾病引起的多器官损伤和功能障碍导致死亡的最佳选择。
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来源期刊
Ethiopian Journal of Health Sciences
Ethiopian Journal of Health Sciences HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.10
自引率
8.30%
发文量
137
审稿时长
12 weeks
期刊介绍: Ethiopian Journal of Health Sciences is a general health science journal addressing clinical medicine, public health and biomedical sciences. Rarely, it covers veterinary medicine
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