Abigail Gaffar MS, Abdul Rahman Alenezi MD, Kathleen M. Kelly MD, Heather M. Kulaga MS, Hsin-Tzu Keng MS, Amy Smith BA, Andrew P. Lane MD
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引用次数: 0
Abstract
Key points
A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab.
Revision sinus surgery immediately prior to dupilumab reduces long-term interleukin (IL)-4/IL-13 tissue mRNA.
Pre-dupilumab revision surgery is associated with reduced tissue eosinophils and GATA-3+ cells.
期刊介绍：
International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy.
International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.
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