Charalampos D Moschopoulos, Kate Alford, Anastasia Antoniadou, Jaime H Vera
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引用次数: 0
Abstract
Despite the dramatic decrease in HIV-associated neurocognitive impairment (NCI) in the combined antiretroviral treatment (cART) era, subtler neuropsychological complications remain prevalent. In this review, we discuss the changing pathophysiology of HIV-associated NCI, considering recent evidence of HIV neuropathogenesis, and the pivotal role of cART. Furthermore, we address the multifactorial nature of NCI in people living with HIV, including legacy and ongoing insults to the brain, as well as host-specific factors. We also summarize the ongoing debate about the refinement of diagnostic criteria, exploring the strengths and limitations of these recent approaches. Finally, we present current research in NCI management in people living with HIV and highlight the need for using both pharmacological and nonpharmacological pathways toward a holistic approach.
尽管在联合抗逆转录病毒治疗（cART）时代，HIV 相关神经认知障碍（NCI）急剧下降，但更微妙的神经心理并发症仍然普遍存在。在这篇综述中，我们讨论了 HIV 相关神经认知障碍不断变化的病理生理学，考虑了 HIV 神经发病机制的最新证据，以及 cART 的关键作用。此外，我们还讨论了 HIV 感染者 NCI 的多因素性质，包括对大脑的遗留和持续损伤，以及宿主特异性因素。我们还总结了目前关于完善诊断标准的争论，探讨了这些最新方法的优势和局限性。最后，我们介绍了目前对艾滋病病毒感染者进行 NCI 管理的研究情况，并强调有必要同时使用药物和非药物方法来实现综合治疗。
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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