Emerging tools and best practices for studying gut microbial community metabolism

IF 18.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nature metabolism Pub Date : 2024-07-03 DOI:10.1038/s42255-024-01074-z
Cecilia Noecker, Peter J. Turnbaugh
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Abstract

The human gut microbiome vastly extends the set of metabolic reactions catalysed by our own cells, with far-reaching consequences for host health and disease. However, our knowledge of gut microbial metabolism relies on a handful of model organisms, limiting our ability to interpret and predict the metabolism of complex microbial communities. In this Perspective, we discuss emerging tools for analysing and modelling the metabolism of gut microorganisms and for linking microorganisms, pathways and metabolites at the ecosystem level, highlighting promising best practices for researchers. Continued progress in this area will also require infrastructure development to facilitate cross-disciplinary synthesis of scientific findings. Collectively, these efforts can enable a broader and deeper understanding of the workings of the gut ecosystem and open new possibilities for microbiome manipulation and therapy. In this Perspective, Noecker and Turnbaugh provide a detailed guide for studying microbial community metabolism and discuss the best practices in the field.

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研究肠道微生物群落代谢的新兴工具和最佳实践
人类肠道微生物群极大地扩展了我们自身细胞催化的一系列代谢反应,对宿主的健康和疾病有着深远的影响。然而,我们对肠道微生物代谢的了解仅限于少数模式生物,这限制了我们解释和预测复杂微生物群落代谢的能力。在本《视角》中,我们将讨论分析和模拟肠道微生物代谢以及在生态系统水平上将微生物、途径和代谢物联系起来的新兴工具,并重点介绍研究人员有望采用的最佳做法。要在这一领域继续取得进展,还需要发展基础设施,以促进科学发现的跨学科综合。总之,这些努力可以让人们更广泛、更深入地了解肠道生态系统的运作,并为微生物组的操作和治疗开辟新的可能性。
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来源期刊
Nature metabolism
Nature metabolism ENDOCRINOLOGY & METABOLISM-
CiteScore
27.50
自引率
2.40%
发文量
170
期刊介绍: Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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