Effect of depression and the antidepressant fluoxetine on osseointegration—A pre-clinical in vivo experimental study

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Oral Implants Research Pub Date : 2024-07-04 DOI:10.1111/clr.14323

Yundeng Xiaowen, Jingxuan Zhu, Mingming Gong, Ge Meng, Renran Tan, Yanbing Zhang, Zhiyu Chen

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Abstract

Objective

The aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.

Methods

Forty-eight 6- to 8-week-old SPF Sprague–Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&Flu group. The rats in the Depression group and the De&Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.

Results

After 12 weeks, bone mineral density was lower in the De&Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone–implant contact (BIC%) in De&Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.

Conclusions

Depression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic–pituitary–adrenal axis and inflammation in the body.

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抑郁症和抗抑郁药氟西汀对骨结合的影响--一项临床前体内实验研究。

研究目的本研究旨在探讨抑郁症和选择性5-羟色胺再摄取抑制剂对种植体骨结合和骨愈合的影响：将 48 只 6 至 8 周大的 SPF Sprague-Dawley 雄性大鼠随机分为四组：对照组、氟西汀组、抑郁组和去氟组。抑郁组和去甲流感组的大鼠接受抑郁建模过程，而对照组和氟西汀组的大鼠则正常饲养。然后，在每只大鼠的右胫骨上植入一个钛植入物。氟西汀组和De&Flu组每天皮下注射氟西汀，对照组和抑郁组每天皮下注射生理盐水。收集用于 ELISA 的大鼠血清。切开手术区域进行微计算机断层扫描和组织学观察：12周后，去甲流感组的骨矿密度低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的骨矿物质密度也低于对照组。去氟大鼠的骨-植入物接触百分比（BIC%）低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的 BIC% 低于对照组：结论：抑郁和氟西汀会单独对骨密度和种植体骨结合产生负面影响，当这两种因素同时存在时，这种破坏性影响会加剧。其机制可能与下丘脑-垂体-肾上腺轴调节失调和体内炎症有关。

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.