Xinxin Han, Qian Deng, Qian Ding, Yajin Li, Shaoxia Pan
Purpose This study aimed to explore the dietary experiences and needs of edentulous patients after full arch implant surgery, and to provide evidence for developing scientific dietary management protocols. Materials and Methods A descriptive qualitative study guided by phenomenological principles was conducted by using purposive sampling. Semi‐structured in‐depth interviews were performed with participants who underwent full arch implant surgery in edentulous jaws. The data were analyzed using thematic analysis, involving familiarizing oneself with the data, generating initial codes, identifying, reviewing, defining, and naming themes, and producing the report. Results Twenty‐one participants, mean age (61.05 ± 7.05) years, were invited and included in the study. Three main themes and nine sub‐themes were identified: Functional food intake limitation (changes in food texture, masticatory dysfunction, limited dietary diversity, decreased food intake); Decline in quality of life (loss of eating enjoyment, excessive dietary restrictions, invisible impairment of social functioning); Need for dietary guidance (urgent demand for professional guidance, content of the requirements and formal preference). Conclusions Edentulous patients undergoing implant surgery experienced multidimensional eating restrictions and dietary challenges. The majority of patients expressed a pressing need for professional dietary guidance to enhance dietary experience and quality of life. During the critical period of osseointegration following edentulous jaw surgery, a combination of conventional and digital methods can be employed to meet patients' information needs and address existing clinical shortcomings. Based on research findings, future efforts are needed to develop a phased progressive dietary guidance protocol tailored to patient needs, aligned with the biological stages of osseointegration.
{"title":"Dietary Experiences and Needs of Edentulous Patients Following Full Arch Implant Surgery: A Qualitative Study","authors":"Xinxin Han, Qian Deng, Qian Ding, Yajin Li, Shaoxia Pan","doi":"10.1111/clr.70092","DOIUrl":"https://doi.org/10.1111/clr.70092","url":null,"abstract":"Purpose This study aimed to explore the dietary experiences and needs of edentulous patients after full arch implant surgery, and to provide evidence for developing scientific dietary management protocols. Materials and Methods A descriptive qualitative study guided by phenomenological principles was conducted by using purposive sampling. Semi‐structured in‐depth interviews were performed with participants who underwent full arch implant surgery in edentulous jaws. The data were analyzed using thematic analysis, involving familiarizing oneself with the data, generating initial codes, identifying, reviewing, defining, and naming themes, and producing the report. Results Twenty‐one participants, mean age (61.05 ± 7.05) years, were invited and included in the study. Three main themes and nine sub‐themes were identified: Functional food intake limitation (changes in food texture, masticatory dysfunction, limited dietary diversity, decreased food intake); Decline in quality of life (loss of eating enjoyment, excessive dietary restrictions, invisible impairment of social functioning); Need for dietary guidance (urgent demand for professional guidance, content of the requirements and formal preference). Conclusions Edentulous patients undergoing implant surgery experienced multidimensional eating restrictions and dietary challenges. The majority of patients expressed a pressing need for professional dietary guidance to enhance dietary experience and quality of life. During the critical period of osseointegration following edentulous jaw surgery, a combination of conventional and digital methods can be employed to meet patients' information needs and address existing clinical shortcomings. Based on research findings, future efforts are needed to develop a phased progressive dietary guidance protocol tailored to patient needs, aligned with the biological stages of osseointegration.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"115 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVESTo evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri-implantitis treatment.MATERIALS AND METHODSThirty-two patients with peri-implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group, CG). Clinical and radiographic parameters were recorded at baseline, 6, and 12 months. The primary outcome was the change in clinical attachment level (CAL), while secondary outcomes included pocket probing depth (PPD), bleeding on probing (BoP), plaque index (PI), keratinized mucosa width (KMW), mucosal thickness (MT), recession (REC), suppuration (SUP), marginal bone levels (MBL), bone defect morphology, and disease resolution (DR).RESULTSAt 12 months, CAL gain was significantly higher in TG compared with CG (3.21 ± 1.57 mm vs. 1.65 ± 1.28 mm; p = 0.022), and TG achieved significantly greater increase in KMW (2.25 ± 2.89 mm vs. 0.26 ± 1.49 mm; p = 0.010). Both groups showed significant PPD reduction, with a greater, though not statistically significant, improvement comparing TG with CG (3.25 ± 1.59 mm vs. 1.97 ± 1.23 mm; p = 0.052). Additionally, MBL improved significantly in both groups (p < 0.001), with higher gains in TG (p < 0.001). However, DR was comparable between the two groups.CONCLUSIONSGBR effectively improves peri-implant parameters after 1 year. Adding a CTG enhances CAL and KMW gains and may promote more favorable bone levels, although the impact on DR remains inconclusive. Long-term studies are warranted to confirm these findings.TRIAL REGISTRATIONClinicalTrials.gov NCT04323540.
目的评价在引导骨再生（GBR）中加入结缔组织移植物（CTG）是否能改善手术治疗种植体周围炎的临床和影像学结果。材料与方法32例种植体周围炎患者随机分为GBR联合CTG组（试验组，TG）和GBR组（对照组，CG）。在基线、6个月和12个月记录临床和影像学参数。主要结果是临床附着水平（CAL）的变化，次要结果包括口袋探测深度（PPD）、探测出血（BoP）、斑块指数（PI）、角化粘膜宽度（KMW）、粘膜厚度（MT）、萎缩（REC）、化脓（SUP）、边缘骨水平（MBL）、骨缺损形态和疾病缓解（DR）。结果12个月后，TG组CAL增益显著高于CG组（3.21±1.57 mm vs. 1.65±1.28 mm, p = 0.022）， TG组KMW组CAL增益显著高于CG组（2.25±2.89 mm vs. 0.26±1.49 mm, p = 0.010）。两组均显示PPD显著降低，TG与CG相比改善更大（3.25±1.59 mm vs. 1.97±1.23 mm; p = 0.052），但无统计学意义。此外，两组MBL均有显著改善（p < 0.001）， TG的改善更高（p < 0.001）。然而，两组之间的DR具有可比性。结论sgbr术后1年可有效改善种植体周围参数。添加CTG可提高CAL和KMW的增加，并可能促进更有利的骨水平，尽管对DR的影响尚不确定。有必要进行长期研究来证实这些发现。临床试验注册。gov NCT04323540。
{"title":"Effect of Connective Tissue Graft as an Adjunct to Guided Bone Regeneration in the Surgical Treatment of Peri-Implantitis: A Dual-Center Randomized Controlled Trial.","authors":"Lucrezia Paterno Holtzman,Iva Milinkovic,Marija Vuckovic,Chiara Malpassi,Marla Cuppini,Alex Solderer,Zoran Aleksic,Luca Cordaro","doi":"10.1111/clr.70093","DOIUrl":"https://doi.org/10.1111/clr.70093","url":null,"abstract":"OBJECTIVESTo evaluate whether adding a connective tissue graft (CTG) to guided bone regeneration (GBR) improves clinical and radiographic outcomes in surgical peri-implantitis treatment.MATERIALS AND METHODSThirty-two patients with peri-implantitis were randomly assigned to receive GBR and CTG (test group, TG) or GBR alone (control group, CG). Clinical and radiographic parameters were recorded at baseline, 6, and 12 months. The primary outcome was the change in clinical attachment level (CAL), while secondary outcomes included pocket probing depth (PPD), bleeding on probing (BoP), plaque index (PI), keratinized mucosa width (KMW), mucosal thickness (MT), recession (REC), suppuration (SUP), marginal bone levels (MBL), bone defect morphology, and disease resolution (DR).RESULTSAt 12 months, CAL gain was significantly higher in TG compared with CG (3.21 ± 1.57 mm vs. 1.65 ± 1.28 mm; p = 0.022), and TG achieved significantly greater increase in KMW (2.25 ± 2.89 mm vs. 0.26 ± 1.49 mm; p = 0.010). Both groups showed significant PPD reduction, with a greater, though not statistically significant, improvement comparing TG with CG (3.25 ± 1.59 mm vs. 1.97 ± 1.23 mm; p = 0.052). Additionally, MBL improved significantly in both groups (p < 0.001), with higher gains in TG (p < 0.001). However, DR was comparable between the two groups.CONCLUSIONSGBR effectively improves peri-implant parameters after 1 year. Adding a CTG enhances CAL and KMW gains and may promote more favorable bone levels, although the impact on DR remains inconclusive. Long-term studies are warranted to confirm these findings.TRIAL REGISTRATIONClinicalTrials.gov NCT04323540.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"82 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F R S Michallek,M Sluka,V C Landwehr,K Vach,L Larsson,K Nelson,S Nahles,F Kernen,G Iglhaut,T Fretwurst
INTRODUCTIONThe aim was the immunohistological evaluation of a porcine dermal matrix (PDM) in comparison to a non-augmented control group for peri-implant tissue thickening.MATERIALS AND METHODSThis human histological study involved the placement of PDM in the test group (20 patients) during implant placement, while the control group underwent implant placement without grafting (20 patients). Postoperative clinical evaluations were conducted, and biopsies were obtained after 3 months. Histomorphometric evaluation utilized H&E staining. Immunohistological analysis included CD31, PSR, TE-7, CD3, CD20, CD138, and CD68.RESULTSA total of 40 patients (17 females, 23 males; 60.62 years) were included. Though more frequent gingival redness occurred during wound healing in the PDM, the groups showed no significant differences in epithelial thickness (p = 0.63), rete ridges (p = 0.53), papilla density (p = 0.626), papilla complexity (p = 0.053), vascularization (p = 0.052), connective tissue morphology (p = 0.127), collagen differentiation (p = 0.41), and CD3+ (p = 0.85) and CD138+ cells (p = 0.33). The PDM group showed significantly more CD68+ cells (p = 0.049) and CD20+ cells (p = 0.046), which correlates with a potentially distinct immune response caused by the PDM.CONCLUSIONThe PDM used in this study exhibited no significant differences regarding epithelial changes, vascularization, tissue morphology, and collagen differentiation compared to a healthy control sample 3 months after grafting. The PDM group demonstrated a significantly higher frequency of CD68+ and CD20+ cells. The noticeable interindividual variation in immunoprofiles and clinical relevance of these findings should be investigated in future research.
{"title":"Immunohistological Evaluation of Peri-Implant Soft Tissue Grafting Using a Porcine Dermal Matrix-A Human Histological Study.","authors":"F R S Michallek,M Sluka,V C Landwehr,K Vach,L Larsson,K Nelson,S Nahles,F Kernen,G Iglhaut,T Fretwurst","doi":"10.1111/clr.70088","DOIUrl":"https://doi.org/10.1111/clr.70088","url":null,"abstract":"INTRODUCTIONThe aim was the immunohistological evaluation of a porcine dermal matrix (PDM) in comparison to a non-augmented control group for peri-implant tissue thickening.MATERIALS AND METHODSThis human histological study involved the placement of PDM in the test group (20 patients) during implant placement, while the control group underwent implant placement without grafting (20 patients). Postoperative clinical evaluations were conducted, and biopsies were obtained after 3 months. Histomorphometric evaluation utilized H&E staining. Immunohistological analysis included CD31, PSR, TE-7, CD3, CD20, CD138, and CD68.RESULTSA total of 40 patients (17 females, 23 males; 60.62 years) were included. Though more frequent gingival redness occurred during wound healing in the PDM, the groups showed no significant differences in epithelial thickness (p = 0.63), rete ridges (p = 0.53), papilla density (p = 0.626), papilla complexity (p = 0.053), vascularization (p = 0.052), connective tissue morphology (p = 0.127), collagen differentiation (p = 0.41), and CD3+ (p = 0.85) and CD138+ cells (p = 0.33). The PDM group showed significantly more CD68+ cells (p = 0.049) and CD20+ cells (p = 0.046), which correlates with a potentially distinct immune response caused by the PDM.CONCLUSIONThe PDM used in this study exhibited no significant differences regarding epithelial changes, vascularization, tissue morphology, and collagen differentiation compared to a healthy control sample 3 months after grafting. The PDM group demonstrated a significantly higher frequency of CD68+ and CD20+ cells. The noticeable interindividual variation in immunoprofiles and clinical relevance of these findings should be investigated in future research.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"3 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Maligno,Ricardo N M J Páscoa,Pedro S Gomes
OBJECTIVESThis study aimed to assess biochemical differences in peri-implant crevicular fluid (PICF) using ATR-FTIR spectroscopy and multivariate analysis, through a between-participant comparison of healthy and peri-implantitis (PI) sites, and a within-participant comparison of PI-PICF and GCF from contralateral periodontal healthy teeth.MATERIALS AND METHODSSamples were categorized into three groups based on peri-implant status and sampling site: PICF from peri-implant healthy sites, PICF from PI-affected sites, and GCF from contralateral healthy teeth in PI patients, with n = 20/group. Samples were collected and analyzed through ATR-FTIR spectroscopy. Chemometric models were applied for cluster/outlier identification and discrimination. Regression coefficient vectors of PLS-DA models identified key spectral differences between groups.RESULTSA total of 40 implants were analyzed; participants had a mean age of 62 years, predominantly female (59%), non-smokers (88%), and most received regular maintenance therapy (82%). PCA revealed subtle cluster formations without clear group separation. Comparing PICF from patients with and without PI, the most important wavenumbers for the PLS-DA model were within 1700-1680 cm-1, 1190-1130 cm-1, and 1050-980 cm-1, associated with protein-related signals and nucleic-acid content. Comparing the GCF and PICF from PI patients, using a split-mouth design, the most important wavenumbers were 3006 cm-1, 2982 cm-1, and 2900 cm-1, related to lipid structures. In terms of accuracy, between-participant assessment achieved 75%, whereas the split-mouth assessment reached 83.4%.CONCLUSIONSFTIR-spectroscopy combined with chemometric modeling effectively discriminates peri-implant health and PI in both inter- and intra-subject comparisons. Higher within-subject accuracy supports FTIR's potential as a site-specific, non-invasive diagnostic tool for peri-implantitis.
{"title":"Peri-Implant Crevicular Fluid Analysis by Mid-Infrared Spectroscopy in Peri-Implantitis-A Pilot Study.","authors":"Francisco Maligno,Ricardo N M J Páscoa,Pedro S Gomes","doi":"10.1111/clr.70091","DOIUrl":"https://doi.org/10.1111/clr.70091","url":null,"abstract":"OBJECTIVESThis study aimed to assess biochemical differences in peri-implant crevicular fluid (PICF) using ATR-FTIR spectroscopy and multivariate analysis, through a between-participant comparison of healthy and peri-implantitis (PI) sites, and a within-participant comparison of PI-PICF and GCF from contralateral periodontal healthy teeth.MATERIALS AND METHODSSamples were categorized into three groups based on peri-implant status and sampling site: PICF from peri-implant healthy sites, PICF from PI-affected sites, and GCF from contralateral healthy teeth in PI patients, with n = 20/group. Samples were collected and analyzed through ATR-FTIR spectroscopy. Chemometric models were applied for cluster/outlier identification and discrimination. Regression coefficient vectors of PLS-DA models identified key spectral differences between groups.RESULTSA total of 40 implants were analyzed; participants had a mean age of 62 years, predominantly female (59%), non-smokers (88%), and most received regular maintenance therapy (82%). PCA revealed subtle cluster formations without clear group separation. Comparing PICF from patients with and without PI, the most important wavenumbers for the PLS-DA model were within 1700-1680 cm-1, 1190-1130 cm-1, and 1050-980 cm-1, associated with protein-related signals and nucleic-acid content. Comparing the GCF and PICF from PI patients, using a split-mouth design, the most important wavenumbers were 3006 cm-1, 2982 cm-1, and 2900 cm-1, related to lipid structures. In terms of accuracy, between-participant assessment achieved 75%, whereas the split-mouth assessment reached 83.4%.CONCLUSIONSFTIR-spectroscopy combined with chemometric modeling effectively discriminates peri-implant health and PI in both inter- and intra-subject comparisons. Higher within-subject accuracy supports FTIR's potential as a site-specific, non-invasive diagnostic tool for peri-implantitis.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"103 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marc Balmer,Michael Payer,Anke Steinwender,Valentin Herber,Ronald E Jung,Sebastian Kühl
OBJECTIVESTo evaluate the clinical performance of two-piece zirconia implants with screw-retained abutments compared to titanium implants after 1 year of loading.MATERIALS AND METHODSIn this multicenter, prospective, randomized clinical trial, 61 two-piece zirconia and 61 titanium implants were placed and restored with single crowns. Evaluations were performed at implant placement, crown delivery, and 1-year post-loading. Peri-implant Marginal Bone Loss (MBL), survival rate, early wound healing index, and soft tissue parameters were assessed. Intergroup comparisons of continuous outcomes were performed using Linear Mixed-Effects Models accounting for center and potential confounders. Categorical variables were analyzed using the chi-square or Fisher's exact test. Survival was analyzed using Kaplan-Meier estimates. Significance was set at p < 0.05.RESULTSNo significant differences were found between the two implant types. Mean MBL from implantation to crown insertion was 1.10 ± 0.78 mm for titanium and 0.94 ± 0.67 mm for zirconia implants. No significant additional bone loss occurred over the subsequent year, with changes of 0.07 ± 0.55 mm and 0.08 ± 0.51 mm for titanium and zirconia, respectively. After 1 year, zirconia implants showed a 100% survival rate, while titanium implants showed 96.5% with two failures. At 1 year, differences in probing depths, plaque accumulation, and Papilla Bleeding Index were not statistically significant.CONCLUSIONAfter 1 year of loading, no statistically significant differences in MBL, implant survival, or peri-implant health were found between zirconia and titanium implants, indicating no clinical superiority. Zirconia implants may therefore be considered a viable alternative in single-tooth implant restorations.TRIAL REGISTRATIONThe study is registered at the German Clinical Trial Register (No. DRKS 00013209) as well as at the Federal Office of Public Health's (FOPH) portal for human research in Switzerland (kofam.ch).
{"title":"One-Year Analysis of Clinical and Radiological Outcomes of Two-Piece Zirconia Compared to Titanium Implants: A Multicenter Prospective Randomized Clinical Trial.","authors":"Marc Balmer,Michael Payer,Anke Steinwender,Valentin Herber,Ronald E Jung,Sebastian Kühl","doi":"10.1111/clr.70094","DOIUrl":"https://doi.org/10.1111/clr.70094","url":null,"abstract":"OBJECTIVESTo evaluate the clinical performance of two-piece zirconia implants with screw-retained abutments compared to titanium implants after 1 year of loading.MATERIALS AND METHODSIn this multicenter, prospective, randomized clinical trial, 61 two-piece zirconia and 61 titanium implants were placed and restored with single crowns. Evaluations were performed at implant placement, crown delivery, and 1-year post-loading. Peri-implant Marginal Bone Loss (MBL), survival rate, early wound healing index, and soft tissue parameters were assessed. Intergroup comparisons of continuous outcomes were performed using Linear Mixed-Effects Models accounting for center and potential confounders. Categorical variables were analyzed using the chi-square or Fisher's exact test. Survival was analyzed using Kaplan-Meier estimates. Significance was set at p < 0.05.RESULTSNo significant differences were found between the two implant types. Mean MBL from implantation to crown insertion was 1.10 ± 0.78 mm for titanium and 0.94 ± 0.67 mm for zirconia implants. No significant additional bone loss occurred over the subsequent year, with changes of 0.07 ± 0.55 mm and 0.08 ± 0.51 mm for titanium and zirconia, respectively. After 1 year, zirconia implants showed a 100% survival rate, while titanium implants showed 96.5% with two failures. At 1 year, differences in probing depths, plaque accumulation, and Papilla Bleeding Index were not statistically significant.CONCLUSIONAfter 1 year of loading, no statistically significant differences in MBL, implant survival, or peri-implant health were found between zirconia and titanium implants, indicating no clinical superiority. Zirconia implants may therefore be considered a viable alternative in single-tooth implant restorations.TRIAL REGISTRATIONThe study is registered at the German Clinical Trial Register (No. DRKS 00013209) as well as at the Federal Office of Public Health's (FOPH) portal for human research in Switzerland (kofam.ch).","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"42 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Roehling,K H Bormann,M M Bornstein,S Laval,F Thieringer,M Gahlert
OBJECTIVESThis study aimed to prospectively investigate the long-term clinical performance of a commercially available one-piece zirconia dental implant system over 10 years.MATERIAL AND METHODSA multicenter, open-label study was conducted at three clinical centers in Germany. Forty-four patients with single-tooth gaps meeting specific inclusion criteria received 44 yttria-stabilized zirconia (Y-TZP) implants featuring a sandblasted and acid-etched (ZLA) surface. Clinical and radiographic follow-ups were performed at 1, 3, 5, and 10 years to assess implant survival, success, peri-implant bone levels, and esthetic outcomes using Pink Esthetic Score (PES) and White Esthetic Score (WES).RESULTSAt the 10-year follow-up, 35 patients with 35 implants were available for evaluation. The estimated 10-year survival rate was 97.7% (95% CI: 97.27-98.13). Three implants (8.6%) showed biological complications, including peri-implant mucositis in 2 implants (5.7%) and peri-implantitis in 1 implant (2.9%), leading to a success rate of 91.4% (95% CI: 76.9-97.8). Peri-implant bone loss was moderate, averaging 1.20 (±0.61) mm over 10 years, with stable bone levels observed after the initial remodeling phase. Esthetic outcomes revealed a slight increase in PES (7.4 to 7.8) and a minor decrease in WES (7.0 to 6.7) between years 5 and 10.CONCLUSIONSZirconia implants demonstrated high long-term survival and success rates, moderate bone loss, and favorable esthetic outcomes. These findings support their use as a clinically reliable and esthetically acceptable long-term alternative to titanium implants. However, the limited sample size highlights the need for further confirmation in larger cohorts.
{"title":"Long-Term Clinical, Radiographic and Esthetic Outcomes of Zirconia Dental Implants: A 10-Year Prospective Multicenter Study.","authors":"S Roehling,K H Bormann,M M Bornstein,S Laval,F Thieringer,M Gahlert","doi":"10.1111/clr.70089","DOIUrl":"https://doi.org/10.1111/clr.70089","url":null,"abstract":"OBJECTIVESThis study aimed to prospectively investigate the long-term clinical performance of a commercially available one-piece zirconia dental implant system over 10 years.MATERIAL AND METHODSA multicenter, open-label study was conducted at three clinical centers in Germany. Forty-four patients with single-tooth gaps meeting specific inclusion criteria received 44 yttria-stabilized zirconia (Y-TZP) implants featuring a sandblasted and acid-etched (ZLA) surface. Clinical and radiographic follow-ups were performed at 1, 3, 5, and 10 years to assess implant survival, success, peri-implant bone levels, and esthetic outcomes using Pink Esthetic Score (PES) and White Esthetic Score (WES).RESULTSAt the 10-year follow-up, 35 patients with 35 implants were available for evaluation. The estimated 10-year survival rate was 97.7% (95% CI: 97.27-98.13). Three implants (8.6%) showed biological complications, including peri-implant mucositis in 2 implants (5.7%) and peri-implantitis in 1 implant (2.9%), leading to a success rate of 91.4% (95% CI: 76.9-97.8). Peri-implant bone loss was moderate, averaging 1.20 (±0.61) mm over 10 years, with stable bone levels observed after the initial remodeling phase. Esthetic outcomes revealed a slight increase in PES (7.4 to 7.8) and a minor decrease in WES (7.0 to 6.7) between years 5 and 10.CONCLUSIONSZirconia implants demonstrated high long-term survival and success rates, moderate bone loss, and favorable esthetic outcomes. These findings support their use as a clinically reliable and esthetically acceptable long-term alternative to titanium implants. However, the limited sample size highlights the need for further confirmation in larger cohorts.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"47 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Momen A Atieh,Maanas Shah,Abeer Hakam,Fawaghi AlAli,Samhar AlSayed,Andrew Tawse-Smith,Nabeel H M Alsabeeha
BACKGROUNDPeri-implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis.OBJECTIVESThis review systematically evaluated the diagnostic performance of deep learning models in detecting peri-implant marginal bone loss on radiographic images.MATERIALS AND METHODSA comprehensive search of PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and ProQuest identified studies published between 2010 and July 2025. Two reviewers independently screened studies, extracted data, and assessed methodological quality using QUADAS-2. Diagnostic metrics, including sensitivity, specificity, F1-score, area under the curve (AUC), were synthesized using random-effects meta-analysis. Heterogeneity and publication bias were evaluated using I2 statistics, meta-regression, and funnel plots.RESULTSFive studies comprising 12,545 periapical and panoramic radiographs met inclusion criteria. Deep learning models achieved pooled sensitivity of 88%, specificity of 91%, and AUC of 0.95, indicating high diagnostic performance. Positive and negative likelihood ratios suggested strong clinical utility. Quality was generally good, though reporting of implant characteristics and data augmentation was inconsistent. Meta-regression revealed that dataset size and unit of analysis influenced accuracy, whereas imaging type did not. No publication bias was found.CONCLUSIONDeep learning models demonstrate high accuracy in detecting radiographic marginal bone loss, potentially indicating peri-implantitis but cannot substitute for comprehensive clinical assessment.CLINICAL RELEVANCEThese models offer a promising adjunct for radiographic detection of marginal bone loss, supporting clinicians in early diagnosis and timely interventions.
{"title":"Diagnostic Accuracy of Deep Learning Models in Detecting Peri-Implant Marginal Bone Loss: A Systematic Review and Meta-Analysis.","authors":"Momen A Atieh,Maanas Shah,Abeer Hakam,Fawaghi AlAli,Samhar AlSayed,Andrew Tawse-Smith,Nabeel H M Alsabeeha","doi":"10.1111/clr.70090","DOIUrl":"https://doi.org/10.1111/clr.70090","url":null,"abstract":"BACKGROUNDPeri-implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis.OBJECTIVESThis review systematically evaluated the diagnostic performance of deep learning models in detecting peri-implant marginal bone loss on radiographic images.MATERIALS AND METHODSA comprehensive search of PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and ProQuest identified studies published between 2010 and July 2025. Two reviewers independently screened studies, extracted data, and assessed methodological quality using QUADAS-2. Diagnostic metrics, including sensitivity, specificity, F1-score, area under the curve (AUC), were synthesized using random-effects meta-analysis. Heterogeneity and publication bias were evaluated using I2 statistics, meta-regression, and funnel plots.RESULTSFive studies comprising 12,545 periapical and panoramic radiographs met inclusion criteria. Deep learning models achieved pooled sensitivity of 88%, specificity of 91%, and AUC of 0.95, indicating high diagnostic performance. Positive and negative likelihood ratios suggested strong clinical utility. Quality was generally good, though reporting of implant characteristics and data augmentation was inconsistent. Meta-regression revealed that dataset size and unit of analysis influenced accuracy, whereas imaging type did not. No publication bias was found.CONCLUSIONDeep learning models demonstrate high accuracy in detecting radiographic marginal bone loss, potentially indicating peri-implantitis but cannot substitute for comprehensive clinical assessment.CLINICAL RELEVANCEThese models offer a promising adjunct for radiographic detection of marginal bone loss, supporting clinicians in early diagnosis and timely interventions.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVESThe increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves outcomes comparable to those observed in the general older population.MATERIALS AND METHODSA first systematic review was reframed to a scoping review using a PCC framework with Population (individuals with neurodegenerative diseases, who were partially or completely edentulous), Concept (implant therapy, planning, placement and maintenance, and any reported complications) and Context (dental and geriatric care settings).RESULTSThe literature search identified 634 studies or case reports, of which none fulfilled the inclusion criteria. Seven papers (1 retrospective study, 2 prospective studies and 4 case reports) outside the inclusion criteria reported on patients with neurodegenerative diseases receiving implants, which suggest that dental implants seem to offer initial benefits in improving chewing efficiency, the quality of life and weight gain, especially in Parkinson's disease (PD) patients. However, their suitability for patients with advanced ND is uncertain.CONCLUSIONAlthough high-level evidence on implant survival and success in patients with neurodegenerative diseases is lacking, the limited available evidence offers promising indications of reasonably successful implant treatments in early-stage cases. However, continuous monitoring of disease progression, oral health and denture management is crucial to retrofit the restoration when necessary.
{"title":"Implant Therapy in Patients With Neurodegenerative Diseases-A Scoping Review.","authors":"Lysandre David,Sabrina Maniewicz,Najla Chebib,Gabriel Gold,Murali Srinivasan,Frauke Müller","doi":"10.1111/clr.70080","DOIUrl":"https://doi.org/10.1111/clr.70080","url":null,"abstract":"OBJECTIVESThe increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves outcomes comparable to those observed in the general older population.MATERIALS AND METHODSA first systematic review was reframed to a scoping review using a PCC framework with Population (individuals with neurodegenerative diseases, who were partially or completely edentulous), Concept (implant therapy, planning, placement and maintenance, and any reported complications) and Context (dental and geriatric care settings).RESULTSThe literature search identified 634 studies or case reports, of which none fulfilled the inclusion criteria. Seven papers (1 retrospective study, 2 prospective studies and 4 case reports) outside the inclusion criteria reported on patients with neurodegenerative diseases receiving implants, which suggest that dental implants seem to offer initial benefits in improving chewing efficiency, the quality of life and weight gain, especially in Parkinson's disease (PD) patients. However, their suitability for patients with advanced ND is uncertain.CONCLUSIONAlthough high-level evidence on implant survival and success in patients with neurodegenerative diseases is lacking, the limited available evidence offers promising indications of reasonably successful implant treatments in early-stage cases. However, continuous monitoring of disease progression, oral health and denture management is crucial to retrofit the restoration when necessary.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"30 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujia Wang, Yiyi Zhu, Xingan Wang, Wenqi Su, Jiahong Shi, Cancan Zu, Lang Lei, Houxuan Li
Objectives Pannexin1 (Panx1), a channel‐forming protein, has been implicated in multiple forms of programmed cell death. This study aimed to investigate the role and underlying molecular mechanisms of Panx1 in regulating ferroptosis during peri‐implantitis (PI). Material and Methods Panx1 expression in PI patients was evaluated through bioinformatics analysis and validated using clinical samples. In vitro, Porphyromonas gingivalis ‐stimulated osteoblasts were assessed for changes in Panx1 and ferroptosis‐related markers. After Panx1 inhibition or knockdown, cellular iron content, reactive oxygen species levels, and lipid peroxidation were measured to evaluate ferroptosis. In vivo, a mouse model of P. gingivalis ‐induced PI was established to evaluate the effects of pharmacological Panx1 inhibition on ferroptosis and peri‐implant bone loss. Results Bioinformatic analysis revealed that Panx1 was significantly upregulated in PI tissue. Clinical samples confirmed that Panx1 expression at both gene and protein levels was markedly elevated in PI tissues compared to healthy controls. In vitro, P. gingivalis upregulated Panx1 expression and induced ferroptosis, characterized by increased lipid peroxidation, iron overload, and ROS accumulation. Panx1 inhibition or knockdown alleviated these ferroptosis‐related changes and was associated with the upregulation of the NRF2/SLC7A11/GPX4 antioxidant signaling pathway. In vivo, Panx1‐inhibited PI mice significantly restored the expression of key anti‐ferroptosis proteins in peri‐implant tissues and markedly reduced vertical and circumferential alveolar bone loss around implants compared to untreated PI mice. Conclusions Panx1 inhibition suppressed P. gingivalis ‐induced ferroptosis in PI accompanied by the upregulation of the NRF2/SLC7A11/GPX4 antioxidant pathway. Targeting Panx1 may provide a potential therapeutic strategy for treating PI.
{"title":"Pannexin1 Inhibition Suppresses Porphyromonas gingivalis ‐Induced Ferroptosis in Peri‐Implantitis by Regulating the NRF2 / SLC7A11 / GPX4 Pathway","authors":"Yujia Wang, Yiyi Zhu, Xingan Wang, Wenqi Su, Jiahong Shi, Cancan Zu, Lang Lei, Houxuan Li","doi":"10.1111/clr.70082","DOIUrl":"https://doi.org/10.1111/clr.70082","url":null,"abstract":"Objectives Pannexin1 (Panx1), a channel‐forming protein, has been implicated in multiple forms of programmed cell death. This study aimed to investigate the role and underlying molecular mechanisms of Panx1 in regulating ferroptosis during peri‐implantitis (PI). Material and Methods Panx1 expression in PI patients was evaluated through bioinformatics analysis and validated using clinical samples. In vitro, <jats:styled-content style=\"fixed-case\"> <jats:italic>Porphyromonas gingivalis</jats:italic> </jats:styled-content> ‐stimulated osteoblasts were assessed for changes in Panx1 and ferroptosis‐related markers. After Panx1 inhibition or knockdown, cellular iron content, reactive oxygen species levels, and lipid peroxidation were measured to evaluate ferroptosis. In vivo, a mouse model of <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐induced PI was established to evaluate the effects of pharmacological Panx1 inhibition on ferroptosis and peri‐implant bone loss. Results Bioinformatic analysis revealed that Panx1 was significantly upregulated in PI tissue. Clinical samples confirmed that Panx1 expression at both gene and protein levels was markedly elevated in PI tissues compared to healthy controls. In vitro, <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> upregulated Panx1 expression and induced ferroptosis, characterized by increased lipid peroxidation, iron overload, and ROS accumulation. Panx1 inhibition or knockdown alleviated these ferroptosis‐related changes and was associated with the upregulation of the NRF2/SLC7A11/GPX4 antioxidant signaling pathway. In vivo, Panx1‐inhibited PI mice significantly restored the expression of key anti‐ferroptosis proteins in peri‐implant tissues and markedly reduced vertical and circumferential alveolar bone loss around implants compared to untreated PI mice. Conclusions Panx1 inhibition suppressed <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐induced ferroptosis in PI accompanied by the upregulation of the NRF2/SLC7A11/GPX4 antioxidant pathway. Targeting Panx1 may provide a potential therapeutic strategy for treating PI.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"53 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shengchi Fan, Wenjie Zhou, Bilal Al-Nawas, Eduard Valmaseda-Castellón, Rubén Davó
Objectives: To evaluate the long-term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full-arch implant rehabilitation in the maxilla due to advanced peri-implantitis.
Material and methods: This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes included the ZI survival and success rates, and secondary outcomes, the prosthetic success rate and complications.
Results: The study population included 28 consecutive patients who received 112 ZIs between 2006 and 2024, with a mean follow-up of 8.2 ± 4.1 years. In 23 patients, a total of 113 failed conventional implants were removed, and 48 ZIs were immediately placed into the explantation sites. The ZI survival rate was 98.2%, with two ZIs requiring removal due to late complications. The implant success rate was 93.5%, and prosthetic success was achieved in 96.4% of cases. Sinusitis was diagnosed in 8 patients (28.5%) at a mean of 5.92 years postoperatively; all cases were successfully managed medically without implant loss. Soft tissue recession occurred in 9.8% of cases, while oroantral fistula and facial fistula were each observed in 0.9% of implants.
Conclusions: The Quad Zygoma Protocol may represent a reliable and predictable option for the rescue of failed maxillary full-arch implant rehabilitations. Despite a relatively high prevalence of sinusitis, favorable long-term clinical outcomes were achieved with appropriate management.
{"title":"Rescue Therapy With Quad Zygoma After Failure of Full-Arch Implant Rehabilitation: A Retrospective Study With a Mean Follow-Up of 8 Years.","authors":"Shengchi Fan, Wenjie Zhou, Bilal Al-Nawas, Eduard Valmaseda-Castellón, Rubén Davó","doi":"10.1111/clr.70086","DOIUrl":"https://doi.org/10.1111/clr.70086","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the long-term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full-arch implant rehabilitation in the maxilla due to advanced peri-implantitis.</p><p><strong>Material and methods: </strong>This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes included the ZI survival and success rates, and secondary outcomes, the prosthetic success rate and complications.</p><p><strong>Results: </strong>The study population included 28 consecutive patients who received 112 ZIs between 2006 and 2024, with a mean follow-up of 8.2 ± 4.1 years. In 23 patients, a total of 113 failed conventional implants were removed, and 48 ZIs were immediately placed into the explantation sites. The ZI survival rate was 98.2%, with two ZIs requiring removal due to late complications. The implant success rate was 93.5%, and prosthetic success was achieved in 96.4% of cases. Sinusitis was diagnosed in 8 patients (28.5%) at a mean of 5.92 years postoperatively; all cases were successfully managed medically without implant loss. Soft tissue recession occurred in 9.8% of cases, while oroantral fistula and facial fistula were each observed in 0.9% of implants.</p><p><strong>Conclusions: </strong>The Quad Zygoma Protocol may represent a reliable and predictable option for the rescue of failed maxillary full-arch implant rehabilitations. Despite a relatively high prevalence of sinusitis, favorable long-term clinical outcomes were achieved with appropriate management.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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