Review of ionic liquid and ionogel-based biomaterials for advanced drug delivery

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-06-26 DOI:10.1016/j.cis.2024.103244

Muzammil Kuddushi , Ben Bin Xu , Naved Malek , Xuehua Zhang

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Abstract

Ionic liquids (ILs) play a crucial role in the design of novel materials. The ionic nature of ILs provides numerous advantages in drug delivery, acting as a green solvent or active ingredient to enhance the solubility, permeability, and binding efficiency of drugs. They could also function as a structuring agent in the development of nano/micro particles for drug delivery, including micelles, vesicles, gels, emulsion, and more. This review summarize the ILs and IL-based gel structures with their advanced drug delivery applications. The first part of review focuses on the role of ILs in drug formulation and the applications of ILs in drug delivery. The second part of review offers a comprehensive overview of recent drug delivery applications of IL-based gel. It aims to offer new perspectives and attract more attention to open up new avenues in the biomedical applications of ILs and IL-based gels.

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基于离子液体和离子凝胶的先进给药生物材料综述。

离子液体（ILs）在新型材料的设计中发挥着至关重要的作用。离子液体的离子性质为药物输送提供了众多优势，可作为绿色溶剂或活性成分，提高药物的溶解度、渗透性和结合效率。在开发纳米/微粒（包括胶束、囊泡、凝胶、乳液等）用于给药时，它们还可以作为一种结构剂。本综述总结了 ILs 和基于 IL 的凝胶结构及其先进的给药应用。综述的第一部分重点介绍了ILs在药物制剂中的作用以及ILs在药物递送中的应用。综述的第二部分全面概述了基于 IL 的凝胶的最新给药应用。综述旨在提供新的视角，吸引更多的关注，为 ILs 和 IL 基凝胶的生物医学应用开辟新的途径。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.