Attenuation Correction of the Cerebellum in PET/MR Data

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-02-27 DOI:10.1109/TRPMS.2024.3370252
Elena Rota Kops;Heba Alrakh;Cláudia Régio Brambilla;Jürgen Scheins;Hans Herzog;N. Jon Shah;Christoph Lerche
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Abstract

Attenuation correction (AC) is essential for achieving artefact-free PET/MR images. Many PET studies use the cerebellum as a reference region; therefore, AC methods should also be tested concerning their performance within the cerebellum. This study compares AC methods for PET/MR data, focusing on the cerebellum. Sixteen subjects underwent an [18F]FDG scan in a 3T-MR-BrainPET insert and a whole-head CT scan on the same day. The CT scan data were transformed into individual CT-based attenuation maps (AMCT), while the MR images were used to derive attenuation maps (AMs) using three methods: 1) Boston-MGH (AM textsubscript MGH); 2) London-UCL (AM textsubscript UCL); and 3) Juelich-Tx-template-based (AM textsubscript Tx-Juel). After reconstruction of the PET data with these four AMs, correlations, coefficients of determination, and relative errors (RErrs) between the PET-AM textsubscript CT and the other three PET-AMs were computed. The cerebellar RErr varied strongly between the three AC methods. The ${\mathrm{ AM}}_{MGH}$ method gave a RErr value of 3.85±5.03%, the AMUCL method gave 6.00±4.54%, and the AMTx-Juelgave 0.25±5.01%. Our results demonstrate that radiotracer uptake quantification in the cerebellum is sensitive to the applied PET AC. This dependency should be especially considered in neuroreceptor studies where the cerebellum is the reference region.
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PET/MR 数据中的小脑衰减校正
衰减校正(AC)对于获得无伪影的 PET/MR 图像至关重要。许多正电子发射计算机断层显像研究都将小脑作为参考区域,因此也应测试 AC 方法在小脑内的性能。本研究以小脑为重点,比较了 PET/MR 数据的 AC 方法。16 名受试者在同一天接受了 3T-MR-BrainPET 插入式[18F]FDG 扫描和全头部 CT 扫描。CT 扫描数据被转换成基于 CT 的单个衰减图 (AMCT),而 MR 图像则被用于使用三种方法得出衰减图 (AM):1) 波士顿-MGH(AM 文本下标 MGH);2) 伦敦-UCL(AM 文本下标 UCL);3) 基于 Juelich-Tx-template 的(AM 文本下标 Tx-Juel)。用这四种 AM 重建 PET 数据后,计算了 PET-AM 文本下标 CT 与其他三种 PET-AM 之间的相关性、决定系数和相对误差 (RErrs)。三种 AC 方法的小脑 RErr 差异很大。${mathrm{ AM}}_{MGH}$方法的RErr值为3.85±5.03%,AMUCL方法为6.00±4.54%,AMTx-Juelgave方法为0.25±5.01%。我们的结果表明,小脑的放射性示踪剂摄取定量对应用的 PET AC 很敏感。在以小脑为参照区的神经受体研究中,应特别考虑这种依赖性。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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