Junyu Xiao, Mengfei Xu, Longchun Wang, Bin Yang, Jingquan Liu
{"title":"Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring","authors":"Junyu Xiao, Mengfei Xu, Longchun Wang, Bin Yang, Jingquan Liu","doi":"10.1007/s42242-024-00283-5","DOIUrl":null,"url":null,"abstract":"<p>监测神经元的电生理活动和血液中的钙离子可以帮助人们更好地了解与疾病相 关的神经系统回路。然而,当前原位钙离子监测工具很少,且大多集成度低、灵 敏度有限。本文提出一种集成原位Ag/AgCl 参比电极(ISA/ARE)的植入式探针, 该探针可以监测动作电位(AP)和Ca<sup>2+</sup>浓度。实验结果表明,Ca<sup>2+</sup>传感器的灵敏 度可达100.7 mV/decade,其在干扰物实验中呈现良好的选择性。本研究通过铂 黑修饰的12 个电生理电极记录到了神经元的AP,而当将CaCl<sub>2</sub> 溶液重复微注射 到大脑的CA1 区域时,Ca<sup>2+</sup>传感器则观察到神经元的可逆电位变化。上述结果 表明,该探针能够满足电生理信号和离子浓度同步监测的需求,加深人们对神经 回路的理解,促进脑科学的发展。</p>","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bio-Design and Manufacturing","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s42242-024-00283-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
期刊介绍:
Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.