Flexible, high-density, laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL Bio-Design and Manufacturing Pub Date : 2024-06-17 DOI:10.1007/s42242-024-00278-2
Yafeng Liu, Zhouheng Wang, Yang Jiao, Ying Chen, Guangyuan Xu, Yinji Ma, Xue Feng
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Abstract

High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization, as the spatial scale of some pathologic signals is at the submillimeter or micrometer level. This entails connecting hundreds or thousands of electrode wires on a limited surface. This study reported a class of flexible, ultrathin, high-density electrocorticogram (ECoG) electrode arrays. The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement. The flexible, ultrathin, high-density ECoG electrode array was conformably attached to the cortex for reliable, high spatial resolution electrophysiologic recordings. The minimum spacing between electrodes was 15 μm, comparable to the diameter of a single neuron. Eight hundred electrodes were prepared with an electrode density of 4444 mm−2. In focal epilepsy surgery, the flexible, high-density, laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves in rabbits, improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level. The flexible, high-density, laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

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用于难治性癫痫高时空分辨率病灶诊断定位的灵活、高密度、层叠式心电图电极阵列
高时空分辨率的脑电信号对于基础神经科学研究和高精度病灶诊断定位至关重要,因为某些病理信号的空间尺度达到亚毫米或微米级。这就需要在有限的表面上连接成百上千根电极线。这项研究报告了一类灵活、超薄、高密度的皮层电图(ECoG)电极阵列。通过层叠结构设计和加工技术改进,克服了大量布线排列的难题。灵活、超薄、高密度的心电图电极阵列与皮层贴合,可进行可靠、高空间分辨率的电生理记录。电极之间的最小间距为 15 微米,与单个神经元的直径相当。共准备了 800 个电极,电极密度为 4444 mm-2。在局灶性癫痫手术中,采用了由 36 个电极组成的柔性高密度层状心电图电极阵列来收集兔子的癫痫尖波,提高了癫痫病灶从厘米级到亚毫米级的定位精度。柔性、高密度、层叠式心电电极阵列在需要高精度脑电图采集的难治性癫痫和其他神经系统疾病中具有潜在的临床应用前景。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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