Recent Developments in MXene-Based Enzyme-Free Electrochemical Glucose Sensing

IF 5.5 3区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS BioChip Journal Pub Date : 2024-06-25 DOI:10.1007/s13206-024-00157-z
Phan Gia Le, Sungbo Cho
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Abstract

Diabetes mellitus is now on the rise worldwide, drawing a lot of attention from scientists. Well-uncontrolled diabetes leads to many serious diseases, including cardiovascular, ophthalmic, and nephrotic. It also caused 6.7 million deaths by 2021 and put a strain on the healthcare system. Therefore, developing useful methods for precisely diagnosing the current glucose concentration can serve as a gold standard for future treatment of diabetes. The classification of electrochemical glucose sensors with and without enzymes has been researched and developed. Among them, the use of enzymes in sensor fabrication results in high costs and easy denaturation in extreme conditions, whereas an enzyme-free approach can overcome these disadvantages and extend life expectancy. To support this, diverse nanomaterials were used, including MXene as an emerging material with favorable physiochemical properties that can be adapted for nonenzymatic electrochemical glucose sensor fabrication. In this study, diabetic disease, synthesis and application of MXene, and electrochemical biosensor were discussed. The application of MXene was thoroughly researched using recent representative publications. Conclusions and prospects for the MXene-based nonenzymatic electrochemical sensor are also explored and discussed.

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基于 MXene 的无酶电化学葡萄糖传感技术的最新进展
目前,糖尿病在全球呈上升趋势,引起了科学家的广泛关注。糖尿病如果得不到有效控制,会引发心血管、眼科、肾病等多种严重疾病。到 2021 年,糖尿病还将导致 670 万人死亡,给医疗系统带来巨大压力。因此,开发精确诊断当前血糖浓度的有用方法可作为未来治疗糖尿病的金标准。人们对含酶和不含酶的电化学葡萄糖传感器进行了分类研究和开发。其中,使用酶制造传感器成本高,在极端条件下容易变性,而无酶方法可以克服这些缺点,延长使用寿命。为此,研究人员使用了多种纳米材料,其中包括具有良好理化特性的新兴材料 MXene,它可用于非酶电化学葡萄糖传感器的制造。本研究讨论了糖尿病、MXene 的合成和应用以及电化学生物传感器。利用最新的代表性出版物对 MXene 的应用进行了深入研究。还探讨和讨论了基于 MXene 的非酶电化学传感器的结论和前景。
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来源期刊
BioChip Journal
BioChip Journal 生物-生化研究方法
CiteScore
7.70
自引率
16.30%
发文量
47
审稿时长
6-12 weeks
期刊介绍: BioChip Journal publishes original research and reviews in all areas of the biochip technology in the following disciplines, including protein chip, DNA chip, cell chip, lab-on-a-chip, bio-MEMS, biosensor, micro/nano mechanics, microfluidics, high-throughput screening technology, medical science, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring and micro/nanotechnology. The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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