Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Drug Metabolism and Pharmacokinetics Pub Date : 2024-05-13 DOI:10.1016/j.dmpk.2023.100992
Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat
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利用相对表达因子 (REF) 和 PET 成像方法预测和验证人体肝胆清除率和运输药物的肝脏浓度
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来源期刊
CiteScore
4.80
自引率
9.50%
发文量
50
审稿时长
69 days
期刊介绍: DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows: - Drug metabolism / Biotransformation - Pharmacokinetics and pharmacodynamics - Toxicokinetics and toxicodynamics - Drug-drug interaction / Drug-food interaction - Mechanism of drug absorption and disposition (including transporter) - Drug delivery system - Clinical pharmacy and pharmacology - Analytical method - Factors affecting drug metabolism and transport - Expression of genes for drug-metabolizing enzymes and transporters - Pharmacogenetics and pharmacogenomics - Pharmacoepidemiology.
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