{"title":"Synthesis, spectroscopic characterization, and in vitro antimicrobial study of novel organotellurium (IV) diphenyldithiocarbamate derivatives","authors":"","doi":"10.1080/17415993.2024.2360441","DOIUrl":null,"url":null,"abstract":"<div><p>Three novel organotellurium (IV) derivatives of diphenyldithiocarbamate, C<sub>4</sub>H<sub>8</sub>Te[(CS<sub>2</sub>) N(C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>]<sub>2</sub> <strong>(1)</strong>, (C<sub>2</sub>H<sub>5</sub>)<sub>2</sub>Te[(CS<sub>2</sub>) N(C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>]<sub>2</sub> <strong>(2)</strong>, and C<sub>4</sub>H<sub>7</sub>(CH<sub>3</sub>)Te[(CS<sub>2</sub>) N(C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>]<sub>2</sub> <strong>(3)</strong> have been synthesized by the reaction of sodium salt of diphenyl dithiocarbamate with C<sub>4</sub>H<sub>8</sub>TeI<sub>2</sub>, (C<sub>2</sub>H<sub>5</sub>)<sub>2</sub>TeI<sub>2</sub>, and C<sub>4</sub>H<sub>7</sub>(CH<sub>3</sub>)TeI<sub>2</sub> respectively. The synthesized compounds <strong>1–3</strong> were characterized by elemental analysis, IR, <sup>1</sup>H NMR, and <sup>13</sup>C{<sup>1</sup>H} NMR spectroscopic studies. The antimicrobial efficacy of compounds <strong>1–3</strong> was examined against selected bacterial and fungal strains using broth microdilution and disc diffusion methods. Penicillin and amphotericin B were used as a positive control for bacterial and fungal strains respectively. The highest activity against bacterial strains was shown by compound <strong>3</strong> while against the fungal strain compound <strong>1</strong> showed the highest activity with a MIC value of 6.25 µg/ml. However, all compounds showed high to moderate antimicrobial activity.</p></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"45 4","pages":"Pages 477-489"},"PeriodicalIF":2.1000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sulfur Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1741599324000163","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Three novel organotellurium (IV) derivatives of diphenyldithiocarbamate, C4H8Te[(CS2) N(C6H5)2]2(1), (C2H5)2Te[(CS2) N(C6H5)2]2(2), and C4H7(CH3)Te[(CS2) N(C6H5)2]2(3) have been synthesized by the reaction of sodium salt of diphenyl dithiocarbamate with C4H8TeI2, (C2H5)2TeI2, and C4H7(CH3)TeI2 respectively. The synthesized compounds 1–3 were characterized by elemental analysis, IR, 1H NMR, and 13C{1H} NMR spectroscopic studies. The antimicrobial efficacy of compounds 1–3 was examined against selected bacterial and fungal strains using broth microdilution and disc diffusion methods. Penicillin and amphotericin B were used as a positive control for bacterial and fungal strains respectively. The highest activity against bacterial strains was shown by compound 3 while against the fungal strain compound 1 showed the highest activity with a MIC value of 6.25 µg/ml. However, all compounds showed high to moderate antimicrobial activity.
期刊介绍：
The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science.
Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.
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