Physico-chemical properties and cytotoxicity of gelatin methacryloyl crosslinked with nanoparticle photoinitiator

IF 2.7 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Materials Research Pub Date : 2024-06-17 DOI:10.1557/s43578-024-01369-7
Kai-Hung Yang, Yizhong Liu, Shelby A. Skoog, Roger J. Narayan
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Abstract

Diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) fabricated into nanoparticle form with increased water dispersibility has enabled broader applications for the bioprinting of hydrogel scaffolds. In this study, the use of TPO NP as a photoinitiator for bioprinting gelatin methacrylate (GelMA) was compared with commonly used lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator by assessing the physico-chemical properties, mechanical strength, gelation kinetics, resistance to flow, absorptivity in different solvents, and biological responses. The results demonstrated that the physico-chemical and mechanical properties of the GelMA were similar using LAP and TPO nanoparticles (NP) for crosslinking. The significant cytotoxicity observed in cells exposed to the GelMA with TPO NP suggests that cell-embedded bioprinting may not be feasible and that removal of toxicant may be needed to utilize GelMA scaffolds crosslinked with TPO NP for biological applications. The results of this study provide a framework for future studies that will consider the microstructure and in vitro properties of GelMA.

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与纳米粒子光引发剂交联的甲基丙烯酰明胶的物理化学特性和细胞毒性
二苯基(2,4,6-三甲基苯甲酰基)氧化膦(TPO)被制成纳米颗粒状,具有更高的水分散性,可广泛应用于水凝胶支架的生物打印。本研究将 TPO NP 作为光引发剂用于甲基丙烯酸明胶(GelMA)的生物打印,并与常用的苯基-2,4,6-三甲基苯甲酰膦酸锂(LAP)光引发剂进行了比较,评估了其物理化学性质、机械强度、凝胶化动力学、流动阻力、在不同溶剂中的吸收性以及生物反应。结果表明,使用 LAP 和 TPO 纳米粒子(NP)交联的 GelMA 的物理化学和机械性能相似。观察到细胞暴露在含有 TPO NP 的 GelMA 中会产生明显的细胞毒性,这表明细胞嵌入式生物打印可能不可行,要将含有 TPO NP 交联的 GelMA 支架用于生物应用,可能需要去除毒性物质。本研究的结果为今后考虑 GelMA 的微观结构和体外特性的研究提供了一个框架。
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来源期刊
Journal of Materials Research
Journal of Materials Research 工程技术-材料科学:综合
CiteScore
4.50
自引率
3.70%
发文量
362
审稿时长
2.8 months
期刊介绍: Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory
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