{"title":"Reactions of trans-[PtX2(pic)2] (Pic = γ-PICOLINE, X = Cl−, NO3 −) with N-acetyl-l-cysteine and glutathione","authors":"Sutopo Hadi, Noviany Noviany, Yandri Yandri","doi":"10.1515/pac-2023-1206","DOIUrl":null,"url":null,"abstract":"The reactions of <jats:italic>trans</jats:italic>-[PtX<jats:sub>2</jats:sub>(pic)<jats:sub>2</jats:sub>] (pic = γ-picoline, X = Cl<jats:sup>−</jats:sup>, NO<jats:sub>3</jats:sub> <jats:sup>−</jats:sup>) with N-acetyl-<jats:sc>l</jats:sc>-cysteine (acSH) and glutathione (GSH) were monitored and followed by <jats:sup>1</jats:sup>H and <jats:sup>195</jats:sup>Pt NMR. In the reaction of <jats:italic>trans</jats:italic>-[Pt(pic)<jats:sub>2</jats:sub>(D<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>](NO<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub> with acSH, in the <jats:sup>195</jats:sup>Pt NMR spectra, the most intense peak observed was <jats:italic>trans</jats:italic>-[Pt(pic)<jats:sub>2</jats:sub>(acS)}<jats:sub>2</jats:sub>(µ-acS)]<jats:sup>+</jats:sup> (3). The intermediate product which was not clearly seen in the spectra was formulated as <jats:italic>trans</jats:italic>-[Pt (pic)<jats:sub>2</jats:sub>(acS)(D<jats:sub>2</jats:sub>O)]<jats:sup>+</jats:sup> (2), with the weaker peak one as <jats:italic>trans</jats:italic>-[Pt(pic)<jats:sub>2</jats:sub>(acS)<jats:sub>2</jats:sub>] (1). With GSH, the main product observed was <jats:italic>trans</jats:italic>-[Pt(pic)<jats:sub>2</jats:sub>(GS)<jats:sub>2</jats:sub>] (4), while the intermediate product was not observed during this study. In the reactions of <jats:italic>trans</jats:italic>-[PtCl<jats:sub>2</jats:sub>(pic)<jats:sub>2</jats:sub>] with acSH, besides complexes 1 and 3 formed, the formation of <jats:italic>trans</jats:italic>-[Pt(pic)<jats:sub>2</jats:sub>Cl(acS)] (6) was also observed in the NMR spectra, while when it was reacted with GSH, followed a similar course to that of with acSH, but more slowly.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"20 1","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pure and Applied Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1515/pac-2023-1206","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The reactions of trans-[PtX2(pic)2] (pic = γ-picoline, X = Cl−, NO3−) with N-acetyl-l-cysteine (acSH) and glutathione (GSH) were monitored and followed by 1H and 195Pt NMR. In the reaction of trans-[Pt(pic)2(D2O)2](NO3)2 with acSH, in the 195Pt NMR spectra, the most intense peak observed was trans-[Pt(pic)2(acS)}2(µ-acS)]+ (3). The intermediate product which was not clearly seen in the spectra was formulated as trans-[Pt (pic)2(acS)(D2O)]+ (2), with the weaker peak one as trans-[Pt(pic)2(acS)2] (1). With GSH, the main product observed was trans-[Pt(pic)2(GS)2] (4), while the intermediate product was not observed during this study. In the reactions of trans-[PtCl2(pic)2] with acSH, besides complexes 1 and 3 formed, the formation of trans-[Pt(pic)2Cl(acS)] (6) was also observed in the NMR spectra, while when it was reacted with GSH, followed a similar course to that of with acSH, but more slowly.
期刊介绍:
Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.