{"title":"The Negative Effects of Smoking Cigarettes on Morphological and Histological Damages to 18 and 21 Days Mouse Embryo Liver","authors":"zahra peyrovi, Soheil Azizi, Mohammad Hosseini","doi":"10.1101/2024.06.22.600226","DOIUrl":null,"url":null,"abstract":"Smoking cigarettes can lead to morphological and histological changes in several human and animal tissues. This paper describes the effects of CS exposure on the liver, weight, and length of mouse embryos. 42 NMRI adult mice were used for mating. Pregnant female mice were categorized into 3 groups: F (filtered), NF (non-filtered), and C (controlled). Each group included 14 female mice exposed to 12 cigarettes daily; 7 mice for 18 days and 7 mice for 21 days. In addition, only the group C were exposed to ambient air. Seven mouse embryos from each group were euthanized. Their livers were fixed for histological processing. The Livers of groups F & NF as compared with group C revealed changes in cellular architecture, centrilobular veins, inflammatory cells, kupffer cells, cytoplasmic vacuolation, hepatocytes necrosis, and decreased parenchymal cellularity. The average weight of embryo, liver, and CR in F & NF significantly reduced (p<0.05 and p<0.01).","PeriodicalId":501471,"journal":{"name":"bioRxiv - Pathology","volume":"28 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.06.22.600226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Smoking cigarettes can lead to morphological and histological changes in several human and animal tissues. This paper describes the effects of CS exposure on the liver, weight, and length of mouse embryos. 42 NMRI adult mice were used for mating. Pregnant female mice were categorized into 3 groups: F (filtered), NF (non-filtered), and C (controlled). Each group included 14 female mice exposed to 12 cigarettes daily; 7 mice for 18 days and 7 mice for 21 days. In addition, only the group C were exposed to ambient air. Seven mouse embryos from each group were euthanized. Their livers were fixed for histological processing. The Livers of groups F & NF as compared with group C revealed changes in cellular architecture, centrilobular veins, inflammatory cells, kupffer cells, cytoplasmic vacuolation, hepatocytes necrosis, and decreased parenchymal cellularity. The average weight of embryo, liver, and CR in F & NF significantly reduced (p<0.05 and p<0.01).
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