{"title":"Supramolecular hydrogels for sustained extracellular vesicle delivery","authors":"Neil Patel, Elijah Avery, Eun Ji Chung","doi":"10.1557/s43579-024-00589-6","DOIUrl":null,"url":null,"abstract":"<p>Extracellular vesicles (EVs) have been explored as promising drug delivery platforms and cell-free therapies for a range of diseases. Despite their therapeutic potential, challenges persist in achieving sustained EV delivery. Here, we integrate EVs into a supramolecular and injectable hydrogel-based drug delivery system based on dodecyl- or octadecyl-modified hydroxypropyl methylcellulose (HPMC-C12 or -C18) that form non-covalent crosslinks with liposomes. Hydrogel mechanics and EV-release kinetics were tunable by varying liposome concentrations. Using mesenchymal stem cell-derived EVs (MSC-EVs), we confirm effective, hydrogel-mediated sustained EV delivery and uptake and a ~ 20% greater anti-inflammatory response in pathogenic vascular smooth muscle cells than bolus EV-only treatment.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":19016,"journal":{"name":"MRS Communications","volume":"19 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MRS Communications","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1557/s43579-024-00589-6","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Extracellular vesicles (EVs) have been explored as promising drug delivery platforms and cell-free therapies for a range of diseases. Despite their therapeutic potential, challenges persist in achieving sustained EV delivery. Here, we integrate EVs into a supramolecular and injectable hydrogel-based drug delivery system based on dodecyl- or octadecyl-modified hydroxypropyl methylcellulose (HPMC-C12 or -C18) that form non-covalent crosslinks with liposomes. Hydrogel mechanics and EV-release kinetics were tunable by varying liposome concentrations. Using mesenchymal stem cell-derived EVs (MSC-EVs), we confirm effective, hydrogel-mediated sustained EV delivery and uptake and a ~ 20% greater anti-inflammatory response in pathogenic vascular smooth muscle cells than bolus EV-only treatment.
期刊介绍：
MRS Communications is a full-color, high-impact journal focused on rapid publication of completed research with broad appeal to the materials community. MRS Communications offers a rapid but rigorous peer-review process and time to publication. Leveraging its access to the far-reaching technical expertise of MRS members and leading materials researchers from around the world, the journal boasts an experienced and highly respected board of principal editors and reviewers.
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