{"title":"Et3N-catalyzed [3 + 2] annulation reaction of β-oxo-acrylamides with diethyl 2-oxomalonates: facile access to oxazolidin-4-one derivatives","authors":"Lingang Wu, Baochuan Guan, Zhaoxue Wang, Lei Xie","doi":"10.1093/chemle/upae116","DOIUrl":null,"url":null,"abstract":"A new and effective method for the [3 + 2] annulation of β-oxo-acrylamides with diethyl 2-oxomalonate, catalyzed by NEt3, has been developed to be carried out under mild reaction conditions. This approach offers a direct route to synthesize oxazolidin-4-one derivatives with yields ranging from 58% to 76%. The process is notable for being highly atom-efficient and operationally simple.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1093/chemle/upae116","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new and effective method for the [3 + 2] annulation of β-oxo-acrylamides with diethyl 2-oxomalonate, catalyzed by NEt3, has been developed to be carried out under mild reaction conditions. This approach offers a direct route to synthesize oxazolidin-4-one derivatives with yields ranging from 58% to 76%. The process is notable for being highly atom-efficient and operationally simple.
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