The effect of CuO dopant on the bioactivity, the biocompatibility, and the antibacterial properties of bioactive glasses synthesized by the sol-gel method
Halima El Bouami, Assia Mabrouk, Cyrille Mercier, Wafa Mihoubi, Edwige Meurice, Claudine Follet, Nadia Faska, Ahmed Bachar
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Abstract
The aim of this study was to investigate the influence of copper (Cu) on bioactivity and on the pathogen inhibition of bioactive glasses (BG) doped with CuO. The BG samples were prepared using a sol-gel method with a molar composition of 55SiO2-(42.5-x) CaO-2.5P2O5-xCuO, where x represents the CuO concentration (0, 1, and 2 mol%). The bioactivity of the glasses was evaluated by immersing them in simulated body fluid (SBF) for 7 and 15 days. Thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to assess the bioactive behavior of the glasses. The results revealed that the bioactive glass doped with 2 mol% CuO exhibited enhanced biocompatibility, as evidenced by the accelerated formation of a hydroxyapatite layer. Furthermore, 29Si and 31P nuclear magnetic resonance (NMR) analysis provided insights into the connectivity of the bioactive glass network upon copper addition. Additionally, an antibacterial test was conducted against Bacillus subtilis, a common pathogen. The results demonstrated that the copper-doped bioactive glass exhibited significant antibacterial activity against Bacillus subtilis, highlighting its potential for promoting the regeneration of hard tissues. Overall, this study contributes to a better understanding of the effects of copper on the bioactivity and antibacterial properties of a new composition of bioactive glasses, which could have important implications in biomedical applications.
期刊介绍：
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.
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