Histomorphometric and microtomographic analysis of maxillary sinus augmentation surgeries with and without collagen membrane on the lateral window: A randomized clinical trial

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Implant Dentistry and Related Research Pub Date : 2024-06-21 DOI:10.1111/cid.13331

Ramiro Beato Souza DDS, MDSc, PhD, Haimon Diniz Lopes Alves DDS, MDSc, PhD, Luciano Santos Oliveira DDS, MDSc, PhD, Fabio Ramoa Pires DDS, MDSc, PhD, Guaracilei Maciel Vidigal Jr DDS, MDSc, PhD, Ricardo Guimaraes Fischer MD, DDS, MDSc, PhD

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Abstract

Objective

To evaluate the histomorphometric and computerized microtomographic (Micro-CT) analysis of the regenerated bone tissue from maxillary sinus augmentation surgery, with and without using the collagen membrane on the external osteotomy window.

Materials and Methods

Twelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split-mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio-Oss® and a Geistlich Bio-Gide® collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio-Oss® was used without the presence of the membrane. After 6 months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro-CT analysis.

Results

In the histomorphometric evaluation, the mean (±SD) percentages of newly formed bone were 43.9% (±11.5) and 40.8% (±8.9) in the test and control groups, respectively. The corresponding values of the Micro-CT analysis were 36.6% (±3.4) and 37.2% (±4.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.

Conclusion

The additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.

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上颌窦侧窗有胶原膜和无胶原膜隆鼻手术的组织形态计量学和显微断层扫描分析：随机临床试验

材料和方法这项前瞻性、对照和随机研究选择了 12 名患者。患者采用分口设计接受双侧上颌窦手术。在试验侧，上颌窦增量手术包括使用 Geistlich Bio-Oss® 和覆盖侧截骨窗的 Geistlich Bio-Gide® 胶原膜。对照组只使用 Geistlich Bio-Oss®，不使用薄膜。6 个月后，进行种植体安装手术。结果在组织形态学评估中，试验组和对照组新形成骨的平均百分比（±SD）分别为 43.9%（±11.5）和 40.8%（±8.9）。在 Micro-CT 分析中，试验组和对照组的相应数值分别为 36.6%（±3.4）和 37.2%（±4.7）。试验组和对照组在两种方法上的差异无统计学意义。此外，试验组和对照组剩余生物材料的平均百分比也没有明显的统计学差异。然而，与通过显微断层扫描获得的数值相比，组织形态计量分析中新形成骨的平均百分比明显更高，而剩余生物材料的平均百分比则明显更低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.