Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-06-20 DOI:10.1007/s11101-024-09980-6
Rui Parente, Ana Cláudia Paiva-Santos, Célia Cabral, Gustavo Costa
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Abstract

Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. Urtica dioica L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of Urtica species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.

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荨麻科植物化学和抗炎特性综述
草药产品被广泛认为有益于多种疾病的预防和治疗,其重要性与日俱增。荨麻(Urtica dioica L.,简称 UD)是一种药用植物,几个世纪以来一直被用作草药疗法和膳食补充剂,其依据是传统经验或随机试验,而没有植物成分方面的专门知识。UD 是一种具有长期抗炎活性记录的草药,其作用机制已被讨论过多次。植物部位、提取溶剂和植物成分对药效和治疗目标都有决定性影响。目前的文献主要阐述了荨麻的抗氧化作用,而荨麻疹的抗炎作用仍是一个需要讨论的问题,因为体外和体内研究的特点仅局限于此。为了详细阐述这一主题,本综述旨在根据体外和体内研究结果,描述几种荨麻提取物的抗炎作用特征,以及对几种病症产生抗炎作用的可能分子和各自的机制。尽管迄今为止已收集了有关荨麻抗炎活性的知识,但仍需进一步研究,以确定其作用机制,并区分荨麻对炎症性疾病产生有益影响的分子。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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