Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.22937
Shaghayegh Hemat Jouy, Jafar Shahraki, Ramin Rezaee, Vahideh Ghorani, Mandana Gholami
{"title":"Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.","authors":"Shaghayegh Hemat Jouy, Jafar Shahraki, Ramin Rezaee, Vahideh Ghorani, Mandana Gholami","doi":"10.22038/AJP.2023.22937","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.</p><p><strong>Materials and methods: </strong>Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.</p><p><strong>Results: </strong>RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group.</p><p><strong>Conclusion: </strong>It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221768/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AJP.2023.22937","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.

Materials and methods: Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.

Results: RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group.

Conclusion: It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
同时服用白藜芦醇和阻力训练可改善丙烯酰胺诱导的大鼠空间学习障碍。
目的:本研究探讨了阻力训练(RT)和白藜芦醇(RES)单独或共同对丙烯酰胺(AC)诱导的大鼠记忆损伤的影响:本研究探讨了阻力训练(RT)和白藜芦醇(RES)单独或共同作用对丙烯酰胺(AC)诱导的大鼠记忆损伤的影响:动物分为 6 组:(1)对照组,每天腹腔注射生理盐水,共8周;(2)东莨菪碱组,每天腹腔注射东莨菪碱1毫克/千克,共8周;(3)丙烯酰胺组,每天腹腔注射丙烯酰胺5毫克/千克,共8周;(4)丙烯酰胺+RT组,每天腹腔注射丙烯酰胺5毫克/千克,共8周,同时进行RT训练(每周5天,共8周);(5) AC + RES 组:接受 AC(5 毫克/千克/天,ip)和 RES(1 毫克/千克/天,ip)治疗,共 8 周;以及 (6) AC + RT + RES 组:接受 AC(5 毫克/千克/天,ip)和 RES(1 毫克/千克/天,ip)治疗,共 8 周,并进行 RT(每周 5 天,共 8 周)。第53天,动物开始接受莫里斯水迷宫(MWM)训练,最后一次训练24小时后,进行探针测试:结果:单独的RT和RES对AC增加的逃逸潜伏期和行进距离没有明显影响。然而,与 AC 组相比,同时使用 RES 和 RT 治疗可显著降低这些参数。与交流组相比,RES和RT联合治疗还能显著增加在目标象限停留的时间。与 AC 组相比,AC+RES 组和 AC+RT+RES 组的脂质过氧化程度降低:结论:每天同时使用 RES 和 RT 治疗 8 周似乎可以改善 AC 对记忆的损害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
期刊最新文献
Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial. An in vitro antiviral evaluation of punicalagin toward influenza A virus. Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats. Comparison of effects of P-coumaric acid and coumarin on colorectal cancer cell line by inducing apoptosis and autophagy. Effect of pretreatment with Devil's Claw on locomotor activity, infarct volume, and neuronal density in focal cerebral ischemia in rats.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1