Pedro Mercader-García, Juan Francisco Silvestre, Francisco Jose Navarro-Triviño, Ana María Giménez-Arnau, María Antonia Pastor-Nieto, Susana Cordoba-Guijarro, Gemma Melé-Ninot, Fátima Tous-Romero, Ricardo González-Pérez, Inmaculada Ruiz-González, Javier Sánchez-Pérez, María Elena Gática-Ortega, Paloma Sánchez-Pedreño, Javier Miquel-Miquel, Javier Ortiz-Frutos, Jose Manuel Carrascosa, Esther Serra-Baldrich, Tatiana Sanz-Sánchez, Victoriano Soria-Aledo, Andrés Carrillo, Leopoldo Borrego, the REIDAC
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引用次数: 0
Abstract
Background
Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients.
Objectives
To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection.
Methods
Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum.
Results
A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37–0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11–0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35–0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol.
Conclusions
In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.
期刊介绍:
Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".