Cancer stem cells: advances in knowledge and implications for cancer therapy.

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-07-05 DOI:10.1038/s41392-024-01851-y
Xianjing Chu, Wentao Tian, Jiaoyang Ning, Gang Xiao, Yunqi Zhou, Ziqi Wang, Zhuofan Zhai, Guilong Tanzhu, Jie Yang, Rongrong Zhou
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Abstract

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity. Cancer continues to be a significant global disease burden. In the past, surgery, radiotherapy, and chemotherapy were the main cancer treatments. The technology of cancer treatments continues to develop and advance, and the emergence of targeted therapy, and immunotherapy provides more options for patients to a certain extent. However, the limitations of efficacy and treatment resistance are still inevitable. Our review begins with a brief introduction of the historical discoveries, original hypotheses, and pathways that regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, and their crosstalk. We focus on the role of CSCs in various therapeutic outcomes and resistance, including how the treatments affect the content of CSCs and the alteration of related molecules, CSCs-mediated therapeutic resistance, and the clinical value of targeting CSCs in patients with refractory, progressed or advanced tumors. In summary, CSCs affect therapeutic efficacy, and the treatment method of targeting CSCs is still difficult to determine. Clarifying regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea.

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癌症干细胞:知识的进步和对癌症治疗的影响。
癌症干细胞(CSCs)是肿瘤中的一小部分细胞,其特点是自我更新和持续增殖,导致肿瘤发生、转移并维持肿瘤的异质性。癌症仍然是全球重大的疾病负担。过去,手术、放疗和化疗是治疗癌症的主要方法。癌症治疗技术不断发展和进步,靶向治疗和免疫治疗的出现在一定程度上为患者提供了更多选择。然而,疗效和耐药性的局限性仍然不可避免。我们的综述首先简要介绍了调控 CSCs 的历史发现、原始假说和通路,如 WNT/β-Catenin、刺猬、Notch、NF-κB、JAK/STAT、TGF-β、PI3K/AKT、PPAR 通路及其交叉作用。我们的研究重点是 CSCs 在各种治疗结果和耐药性中的作用,包括治疗如何影响 CSCs 的含量及相关分子的改变、CSCs 介导的治疗耐药性,以及针对难治性、进展期或晚期肿瘤患者的 CSCs 的临床价值。总之,CSCs会影响疗效,而靶向CSCs的治疗方法仍难以确定。明确CSCs的调控机制和靶向生物标志物是目前的主流思路。
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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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