Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy.

IF 6.1 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell and Bioscience Pub Date : 2024-07-04 DOI:10.1186/s13578-024-01270-0
Ruiming Han, Dongdong Zhu, Jichao Sha, Boning Zhao, Peng Jin, Cuida Meng
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Abstract

Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic dermatitis, and food allergies. These complex conditions arise from the intricate interplay between genetic and environmental factors and are known to contribute to socioeconomic burdens globally. Recent advancements in the study of allergic diseases have illuminated the crucial role of DNA methylation (DNAm) in their pathogenesis. This review explores the factors influencing DNAm in allergic diseases and delves into their mechanisms, offering valuable perspectives for clinicians. Understanding these epigenetic modifications aims to lay the groundwork for improved early prevention strategies. Moreover, our analysis of DNAm mechanisms in these conditions seeks to enhance diagnostic and therapeutic approaches, paving the way for more effective management of allergic diseases in the future.

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解码 DNA 甲基化在过敏性疾病中的作用:从发病机制到治疗。
过敏性疾病具有广泛的临床表现和症状,包括哮喘、过敏性鼻炎、特应性皮炎和食物过敏等一大类 IgE 介导的特应性疾病。这些复杂的病症源于遗传和环境因素之间错综复杂的相互作用,众所周知,它们在全球范围内造成了社会经济负担。过敏性疾病研究的最新进展揭示了 DNA 甲基化(DNAm)在其发病机制中的关键作用。这篇综述探讨了影响过敏性疾病中 DNAm 的因素,并深入研究了其机制,为临床医生提供了宝贵的视角。了解这些表观遗传修饰旨在为改进早期预防策略奠定基础。此外,我们对这些病症中 DNAm 机制的分析旨在加强诊断和治疗方法,为将来更有效地治疗过敏性疾病铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell and Bioscience
Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.70
自引率
0.00%
发文量
187
审稿时长
>12 weeks
期刊介绍: Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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