Transcranial direct current stimulation and cognitive changes in Parkinson's disease, a systematic review with meta-analysis and meta-regression.

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY Applied Neuropsychology-Adult Pub Date : 2024-07-05 DOI:10.1080/23279095.2024.2367108

Jandirlly Julianna de Souza Souto, Milena Edite Casé de Oliveira, Gabriella Medeiros Silva, José Marcos Nascimento de Sousa, Carlúcia Ithamar Fernandes Franco, Natanael Antonio Dos Santos

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Abstract

Parkinson's disease is the second most common neurodegenerative disease, but therapeutic options such as neuromodulation continue to show variable effects, making clinical management of the disease difficult. This systematic review with meta-analysis and meta-regression aimed to analyze the isolated effect of cortical modulation with transcranial direct current stimulation (tDCS) compared to sham stimulation on cognitive changes in people with Parkinson's disease. The databases used were: Web of Science, Scopus, PsycINFO, PubMed, and Cochrane. The results showed that tDCS can influence the improvement of cognition in PD (Inverse Variance:0.24 [95% Confidence Interval: 0.09 to -0.40], p < 0.00). The meta-analysis showed that active tDCS can influence cognitive function by improving aspects related to memory (Inverse Variance:0.34 [95% Confidence Interval: 0.07 to 0.61], p < 0.01) and reducing reaction time in cognitive tasks (Inverse Variance:0.42 [95% Confidence Interval: 0.07 to 0.76], p < 0.02). Innovative meta-regression analyses showed that variables such as age (Q = 2.54, df = 1, p < 0.11), education level (Q = 2.62, df = 1, p < 0.10), disease duration (Q = 0.01, df = 1, p < 0.92), and Unified PD Rating Scale stage (Q = 0.01, df = 1, p < 0.92) did not influence the results. Thus, tDCS may be a therapeutic option for cognitive changes in people with PD, and we suggest further studies to identify protocols that can be replicated.

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经颅直流电刺激与帕金森病患者的认知变化，一项包含荟萃分析和荟萃回归的系统性综述。

帕金森病是第二大最常见的神经退行性疾病，但神经调节等治疗方案的效果仍然参差不齐，给疾病的临床治疗带来了困难。本系统综述采用荟萃分析和荟萃回归的方法，旨在分析经颅直流电刺激（tDCS）与假刺激相比对帕金森病患者认知变化的单独影响。使用的数据库包括Web of Science、Scopus、PsycINFO、PubMed 和 Cochrane。结果表明，tDCS 可影响帕金森病患者认知能力的改善（逆方差：0.24 [95% 置信区间：0.09 至 -0.40]，P P P P P P P

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.