Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.23357
Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki
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Abstract

Objective: Most polycystic ovary syndrome (PCOS) patients have metabolic abnormalities in which insulin resistance (IR) plays a pivotal role. Cinnamon is a herbal medicine with insulinotropic properties. This pilot study aimed to evaluate the effects of cinnamon on ovarian volume, androgenic profile, and metabolic and anthropometric parameters in women with PCOS.

Materials and methods: A single-center, double-blind, randomized, placebo-controlled trial was carried out on 39 overweight / obese women with PCOS. For six months, subjects in the cinnamon (500 mg) (n=19) and placebo (n=20) groups were given three capsules daily. Before and after the intervention, the variables were assessed. The data was analyzed using the GraphPad Prism software.

Results: After the intervention, the two intervention and control groups had significant differences in abdominal subcutaneous fat and ovarian volume, but they did not differ significantly in terms of body mass index (BMI). Also, after the intervention, no significant difference was observed between the two groups in terms of lipid profile and the concentration of androgenic biomarkers of insulin resistance.

Conclusion: Cinnamon supplementation improves ovarian volume and subcutaneous abdominal fat but has no effect on anthropometric parameters, lipid profile, insulin resistance, or androgen hormones.

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肉桂诱导多囊卵巢综合征妇女的代谢和内分泌变化:一项试点研究。
目的:大多数多囊卵巢综合征(PCOS)患者都存在代谢异常,其中胰岛素抵抗(IR)起着关键作用。肉桂是一种具有促胰岛素作用的草药。这项试验性研究旨在评估肉桂对多囊卵巢综合征女性卵巢体积、雄激素谱、代谢和人体测量参数的影响:对 39 名患有多囊卵巢综合征的超重/肥胖妇女进行了单中心、双盲、随机、安慰剂对照试验。在为期六个月的时间里,肉桂(500 毫克)组(19 人)和安慰剂组(20 人)的受试者每天服用三粒肉桂胶囊。对干预前后的变量进行了评估。数据使用 GraphPad Prism 软件进行分析:结果:干预后,干预组和对照组在腹部皮下脂肪和卵巢体积方面有显著差异,但在体重指数(BMI)方面没有显著差异。此外,干预后,两组在血脂状况和胰岛素抵抗的雄激素生物标志物浓度方面也没有明显差异:结论:补充肉桂能改善卵巢体积和腹部皮下脂肪,但对人体测量参数、血脂状况、胰岛素抵抗或雄性激素没有影响。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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