Effects of Gene Alternative Splicing Events on Resistance to Cryptocaryonosis of Large Yellow Croaker (Larimichthys crocea)

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Marine Biotechnology Pub Date : 2024-07-06 DOI:10.1007/s10126-024-10342-8
Xin Li, Qiaozhen Ke, Ang Qu, Jiaying Wang, Ji Zhao, Peng Xu, Tao Zhou
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Abstract

Large yellow croaker (L. crocea) is a productive species in marine aquaculture with great economic value in China. However, the sustainable development of large yellow croaker is hampered by various diseases including cryptocaryonosis caused by Cryptocaryon irritans. The genetic regulation processes for cryptocaryonosis in large yellow croaker are still unclear. In this present study, we analyzed differential alternative splicing events between a C. irritans resistance strain (RS) and a commercial strain (CS). We identified 678 differential alternative splicing (DAS) events from 453 genes in RS and 719 DAS events from 500 genes in CS. A set of genes that are specifically alternatively spliced in RS was identified including mfap5, emp1, and trim33. Further pathway analysis revealed that the specifically alternative spliced genes in RS were involved in innate immune responses through the PRR pathway and the Toll and Imd pathway, suggesting their important roles in the genetic regulation processes for cryptocaryonosis in large yellow croaker. This study would be helpful for the studies of the pathogenesis of cryptocaryonosis and dissection of C. irritans resistance for L. crocea.

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基因替代剪接事件对大黄鱼(Larimichthys crocea)抗隐鞭虫病的影响。
大黄鱼(L. crocea)是中国海水养殖业的高产鱼种,具有很高的经济价值。然而,大黄鱼的可持续发展却受到各种疾病的阻碍,其中包括由隐核虫引起的隐核虫病。大黄鱼隐核虫病的遗传调控过程尚不清楚。在本研究中,我们分析了隐鞭毛虫抗性菌株(RS)和商业菌株(CS)之间的差异替代剪接事件。我们从 RS 的 453 个基因中发现了 678 个差异替代剪接(DAS)事件,从 CS 的 500 个基因中发现了 719 个 DAS 事件。我们发现了一组在 RS 中具有特异性替代剪接的基因,包括 mfap5、emp1 和 trim33。进一步的通路分析表明,RS中的特异性替代剪接基因通过PRR通路以及Toll和Imd通路参与先天性免疫反应,这表明它们在大黄鱼隐鞭虫病的遗传调控过程中发挥着重要作用。这项研究将有助于隐核虫病发病机制的研究和大黄鱼对C. irritans抗性的分析。
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来源期刊
Marine Biotechnology
Marine Biotechnology 工程技术-海洋与淡水生物学
CiteScore
4.80
自引率
3.30%
发文量
95
审稿时长
2 months
期刊介绍: Marine Biotechnology welcomes high-quality research papers presenting novel data on the biotechnology of aquatic organisms. The journal publishes high quality papers in the areas of molecular biology, genomics, proteomics, cell biology, and biochemistry, and particularly encourages submissions of papers related to genome biology such as linkage mapping, large-scale gene discoveries, QTL analysis, physical mapping, and comparative and functional genome analysis. Papers on technological development and marine natural products should demonstrate innovation and novel applications.
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