Web-based prognostic tools for oral tongue cancer: An analysis of online predictors.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI:10.1111/odi.15009

Awais Wahab, Ibrahim O Bello, Rasheed Omobolaji Alabi, Marco Mascitti, Giuseppe Troiano, Matti Mauramo, Ricardo D Coletta, Tuula Salo, Alhadi Almangush

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Abstract

Background: Oral tongue squamous cell carcinoma (OTSCC) often presents with aggressive clinical behaviour that may require multimodality treatment based on reliable prognostication. We aimed to evaluate the prognostic ability of five online web-based tools to predict the clinical behaviour of OTSCC resection and biopsy samples.

Methods: A total of 135 OTSCC resection cases and 33 OTSCC biopsies were included to predict recurrence and survival. Area under the receiver operating characteristic curves (AUC), χ² tests, and calibration plots constructed to estimate the prognostic power of each tool.

Results: The tool entitled 'Prediction of risk of Locoregional Recurrences in Early OTSCC' presented an accuracy of 82%. The tool, 'Head & Neck Cancer Outcome Calculator' for 10-year cancer-related mortality had an accuracy 77% and AUC 0.858. The other tool entitled 'Cancer Survival Rates' for 5-year mortality showed an accuracy of 74% and AUC of 0.723. For biopsy samples, 'Cancer Survival Prediction Calculators' predicted the recurrence free survival with an accuracy of 70%.

Conclusions: Web-based tools can aid in clinical decision making of OTSCC. Three of five online web-based tools could predict recurrence risk and cancer-related mortality in resected OTSCC and one tool could help in clinical decision making for biopsy samples.

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基于网络的口腔舌癌预后工具：在线预测指标分析。

背景：口腔舌鳞状细胞癌（OTSCC）通常具有侵袭性临床表现，可能需要基于可靠预后的多模式治疗。我们旨在评估五种在线网络工具预测 OTSCC 切除和活检样本临床表现的预后能力：方法：共纳入135例OTSCC切除病例和33例OTSCC活检样本，以预测复发率和生存率。通过构建接收者操作特征曲线下面积（AUC）、χ2检验和校准图来估计每种工具的预后能力：结果：名为 "早期OTSCC局部复发风险预测 "的工具准确率为82%。头颈部癌症结果计算器 "工具预测 10 年癌症相关死亡率的准确率为 77%，AUC 为 0.858。另一款名为 "癌症生存率 "的工具对 5 年死亡率的准确率为 74%，AUC 为 0.723。对于活检样本，"癌症生存率预测计算器 "预测无复发生存率的准确率为 70%：结论：基于网络的工具有助于OTSCC的临床决策。五种在线网络工具中有三种可以预测切除的OTSCC的复发风险和癌症相关死亡率，一种工具可以帮助活检样本的临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.