Bariatric Surgery Effect on the Crosstalk of PAI-1 and PCSK9 to Regulate the Metabolic Changes in Patients with Obesity

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-07-01 DOI:10.1016/j.arcmed.2024.103032
Violeta Castro-Leyva , Leticia Manuel-Apolinar , Norma Eleane Basurto-Acevedo , Lourdes Basurto , Antonio González-Chávez , Edith Ruiz-Gastelum , Carlos Martínez-Murillo
{"title":"Bariatric Surgery Effect on the Crosstalk of PAI-1 and PCSK9 to Regulate the Metabolic Changes in Patients with Obesity","authors":"Violeta Castro-Leyva ,&nbsp;Leticia Manuel-Apolinar ,&nbsp;Norma Eleane Basurto-Acevedo ,&nbsp;Lourdes Basurto ,&nbsp;Antonio González-Chávez ,&nbsp;Edith Ruiz-Gastelum ,&nbsp;Carlos Martínez-Murillo","doi":"10.1016/j.arcmed.2024.103032","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Adiposity favors several metabolic disorders with an exacerbated chronic pro-inflammatory status and tissue damage, with high levels of plasminogen activator inhibitor type 1 (PAI-1) and proprotein convertase subtilisin/kexin type 9 (PCSK9).</p></div><div><h3>Objective</h3><p>To demonstrate the influence of bariatric surgery on the crosstalk between PAI-1 and PCSK9 to regulate metabolic markers.</p></div><div><h3>Methods</h3><p>Observational and longitudinal study of 190 patients with obesity and obesity-related comorbidities who underwent bariatric surgery. We measured, before and after bariatric surgery, the anthropometric variables and we performed biochemical analysis by standard methods (glucose, insulin, triglycerides [TG], total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C] and TG/HDL-C ratio, PAI-1 and PCSK9 were measured by ELISA).</p></div><div><h3>Results</h3><p>PAI-1 levels decreased significantly after bariatric surgery, and were positively correlated with lipids, glucose, and TG, with significance on PCSK9 and TG/HDL-C alleviating the insulin resistance (IR) and inducing a state reversal of type 2 diabetes (T2D) with a significant decrease in body weight and BMI (<em>p</em> &lt;0.0001). Multivariate regression analysis predicted a functional model in which PAI-1 acts as a regulator of PCSK9 (<em>p</em> &lt;0.002), TG (<em>p</em> &lt;0.05), and BMI; at the same time, PCSK9 modulates LDL-C HDL-C and PAI-1.</p></div><div><h3>Conclusions</h3><p>After bariatric surgery, we found a positive association and crosstalk between PAI-1 and PCSK9, which modulates the delicate balance of cholesterol, favoring the decrease of circulating lipids, TG, and PAI-1, which influences the glucose levels with amelioration of IR and T2D, demonstrating the crosstalk between fibrinolysis and lipid metabolism, the two main factors involved in atherosclerosis and cardiovascular disease in human obesity.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0188440924000845","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Adiposity favors several metabolic disorders with an exacerbated chronic pro-inflammatory status and tissue damage, with high levels of plasminogen activator inhibitor type 1 (PAI-1) and proprotein convertase subtilisin/kexin type 9 (PCSK9).

Objective

To demonstrate the influence of bariatric surgery on the crosstalk between PAI-1 and PCSK9 to regulate metabolic markers.

Methods

Observational and longitudinal study of 190 patients with obesity and obesity-related comorbidities who underwent bariatric surgery. We measured, before and after bariatric surgery, the anthropometric variables and we performed biochemical analysis by standard methods (glucose, insulin, triglycerides [TG], total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C] and TG/HDL-C ratio, PAI-1 and PCSK9 were measured by ELISA).

Results

PAI-1 levels decreased significantly after bariatric surgery, and were positively correlated with lipids, glucose, and TG, with significance on PCSK9 and TG/HDL-C alleviating the insulin resistance (IR) and inducing a state reversal of type 2 diabetes (T2D) with a significant decrease in body weight and BMI (p <0.0001). Multivariate regression analysis predicted a functional model in which PAI-1 acts as a regulator of PCSK9 (p <0.002), TG (p <0.05), and BMI; at the same time, PCSK9 modulates LDL-C HDL-C and PAI-1.

Conclusions

After bariatric surgery, we found a positive association and crosstalk between PAI-1 and PCSK9, which modulates the delicate balance of cholesterol, favoring the decrease of circulating lipids, TG, and PAI-1, which influences the glucose levels with amelioration of IR and T2D, demonstrating the crosstalk between fibrinolysis and lipid metabolism, the two main factors involved in atherosclerosis and cardiovascular disease in human obesity.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
减肥手术对 PAI-1 和 PCSK9 相互调节肥胖症患者代谢变化的影响
背景肥胖会导致多种代谢紊乱,加剧慢性促炎状态和组织损伤,并伴有高水平的纤溶酶原激活物抑制剂1型(PAI-1)和蛋白转换酶亚基酶/kexin 9型(PCSK9)。方法对 190 名接受减肥手术的肥胖和肥胖相关合并症患者进行观察和纵向研究。我们测量了减肥手术前后的人体测量变量,并用标准方法进行了生化分析(葡萄糖、胰岛素、甘油三酯[TG]、总胆固醇、高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]和TG/HDL-C比值,用ELISA法测定了PAI-1和PCSK9)。结果 减肥手术后 PAI-1 水平明显下降,并与血脂、血糖和 TG 呈正相关,PCSK9 和 TG/HDL-C 对减轻胰岛素抵抗(IR)和诱导 2 型糖尿病(T2D)状态逆转具有重要意义,体重和体重指数(BMI)明显下降(p <0.0001)。多变量回归分析预测了一个功能模型,其中 PAI-1 是 PCSK9(p <0.002)、TG(p <0.05)和 BMI 的调节因子;同时,PCSK9 还调节 LDL-C HDL-C 和 PAI-1。结论减肥手术后,我们发现 PAI-1 和 PCSK9 之间存在正相关和串联关系,PCSK9 可调节胆固醇的微妙平衡,有利于降低循环血脂、总胆固醇和 PAI-1,而 PAI-1 可影响血糖水平,改善 IR 和 T2D,这表明纤溶和脂质代谢之间存在串联关系,而这两个因素是人类肥胖症中动脉粥样硬化和心血管疾病的两个主要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
期刊最新文献
Influence of hormonal factors, number of sexual partners, surgical intervention on gastrointestinal and urogenital microbiota of patients endometriosis Relevance of Circulating microRNA, and their Association with Islet Cell Autoantibodies in Type 1 Diabetes Pathogenesis Features and allele frequency of JAK2 Exon 12-mutated polycythemia vera in comparison with JAK2V617F-mutated disease Overview of hyperprolactinemia: General approach and reproductive health implications Lethal synergistic infections by two concurrent respiratory pathogens
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1