A novel multi-drugs ciprofloxacin-curcumin-N-acetylcysteine co-delivery system based on hybrid nanocrystals for dry powder inhalations

Next Nanotechnology Pub Date : 2024-01-01 DOI:10.1016/j.nxnano.2024.100084

Yingying Ma , Zhufeng Cong , Yancai Wang , Peng Gao

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Abstract

This study designed a novel multi-drugs co-delivery system of ciprofloxacin-curcumin-N-acetylcysteine based on hybrid nanocrystals technology for dry powder inhalations (DPIs). The particle size of PVP k-30 stabilized curcumin nanosuspensions and Poloxamer 188 stabilized ciprofloxacin - N-acetylcysteine (NAC) hybrid nanocrystals was 219.2±4.6 nm and 346.3±7.3 nm, respectively (n=3). The curcumin nanosuspensions was solidified with ciprofloxacin - N-acetylcysteine (NAC) hybrid nanocrystals accompanied by the L-leucine to improve the dispersion of the DPIs. The dispersion, uniformity and fluidity of the spray-dried ciprofloxacin - N-acetylcysteine - curcumin (CPFX/NAC/Cur) nanosuspensions superior to the freeze-dried DPIs. The ciprofloxacin and curcumin of the CPFX/NAC/Cur DPIs obtained by spray-drying with mannitol was amorphous form, and thereby the dispersibility and solubility would be further improved. The four components complex DPIs delivery system designed in this study could give full play to the effects of each component, and then produce synergistic results. Therefore, this multi-drugs ciprofloxacin-curcumin-N-acetylcysteine co-delivery system based on hybrid nanocrystals has the potential to be used in the clinical treatment of pulmonary infections to improve the treatment effect and quality of life of patients.

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基于混合纳米晶体的新型环丙沙星-姜黄素-N-乙酰半胱氨酸多药干粉吸入共给药系统

本研究设计了一种基于混合纳米晶体技术的新型环丙沙星-姜黄素-N-乙酰半胱氨酸多药联合给药系统，用于干粉吸入（DPIs）。PVP k-30 稳定化姜黄素纳米悬浮剂和 Poloxamer 188 稳定化环丙沙星-N-乙酰半胱氨酸（NAC）杂化纳米晶体的粒径分别为 219.2±4.6 nm 和 346.3±7.3 nm（n=3）。将姜黄素纳米悬浮液与环丙沙星-N-乙酰半胱氨酸（NAC）杂化纳米晶体和 L-亮氨酸一起固化，以改善 DPIs 的分散性。喷雾干燥的环丙沙星-N-乙酰半胱氨酸-姜黄素（CPFX/NAC/Cur）纳米悬浮液的分散性、均匀性和流动性优于冷冻干燥的 DPIs。用甘露醇喷雾干燥得到的 CPFX/NAC/Cur DPI 中的环丙沙星和姜黄素呈无定形，因此分散性和溶解性会进一步提高。本研究设计的四组分复合 DPIs 给药系统可充分发挥各组分的作用，进而产生协同效果。因此，这种基于杂化纳米晶体的环丙沙星-姜黄素-N-乙酰半胱氨酸多药联合给药系统有望应用于肺部感染的临床治疗，以提高治疗效果和患者的生活质量。

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