Next Nanotechnology最新文献

Gabapentin loaded nano-emulsion for the effective treatment of peripheral neurological pain: Formulation, characterization, and ex vivo studies 加巴喷丁纳米乳剂对周围神经疼痛的有效治疗：配方、表征和离体研究

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-16 DOI: 10.1016/j.nxnano.2025.100354

Bhavna , Mohit Kumar , Ayesha Siddiqui , Syed Mahmood , Pooja Jain , M. Aamir Mirza , Zeenat Iqbal

Peripheral neuropathic pain remains a major clinical challenge due to its multifactorial pathophysiology and the limited efficacy of available therapies. Gabapentin, an anticonvulsant agent, has shown potential in alleviating neuropathic pain symptoms; however, its therapeutic performance is restricted by poor aqueous solubility and dose-dependent adverse effects. Nano emulsion-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and targeted delivery to peripheral nerves. In the present study, the authors developed a gabapentin-loaded nanoemulsion. The developed nanoemulsion was optimized through systematic excipient screening, construction of pseudo-ternary phase diagrams, and comprehensive evaluation of physicochemical and performance parameters. The optimized formulation demonstrated a cumulative drug release with 97.42 ± 1.23 % (n = 3) within 2 h, indicating rapid and efficient drug release kinetics. Transmission electron microscopy confirmed the uniform nanoscale droplet morphology, while rheological analysis revealed favorable viscosity and spreadability characteristics. The ex vivo skin permeation study revealed a marked improvement in transdermal delivery of gabapentin, which was further supported by FT-IR and DSC results showing disruption of the skin’s lipid bilayer after treatment. The observations from confocal laser scanning microscopy confirmed that the formulation enabled deeper penetration of the drug into the skin layers. These results indicate that the optimized gabapentin nanoemulsion could enhance bioavailability and enable targeted delivery, offering promise for the management of peripheral neuropathic pain. However, the authors also highlight that in vivo efficacy studies will be essential to validate these findings and fully establish the therapeutic potential of the microemulsion.

由于其多因素病理生理和现有治疗方法的有效性有限，周围神经性疼痛仍然是一个主要的临床挑战。加巴喷丁，一种抗惊厥药，已显示出减轻神经性疼痛症状的潜力；然而，其治疗性能受到水溶性差和剂量依赖性不良反应的限制。纳米乳化给药系统提供了一种很有前途的策略，通过增强溶解性、稳定性和对周围神经的靶向递送来克服这些限制。在本研究中，作者开发了一种加巴喷丁负载的纳米乳。通过系统的赋形剂筛选、拟三元相图的构建、理化参数和性能参数的综合评价，对制备的纳米乳进行了优化。2 h内累积释药率为97.42 ± 1.23 % (n = 3)，具有快速有效的释药动力学。透射电镜证实了均匀的纳米级液滴形态，而流变学分析显示了良好的粘度和铺展特性。体外皮肤渗透研究显示加巴喷丁的透皮给药有明显改善，FT-IR和DSC结果显示治疗后皮肤脂质双分子层的破坏进一步支持了这一点。共聚焦激光扫描显微镜观察证实，该配方使药物更深地渗透到皮肤层。这些结果表明，优化后的加巴喷丁纳米乳可以提高生物利用度，实现靶向给药，为治疗周围神经性疼痛提供了希望。然而，作者也强调，体内疗效研究对于验证这些发现和充分确立微乳的治疗潜力至关重要。

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引用次数: 0

Light attenuation and optical absorption characteristics of graphene-chitosan nanomaterials-based quandary nanocomposites 石墨烯-壳聚糖纳米复合材料的光衰减和光吸收特性

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-30 DOI: 10.1016/j.nxnano.2025.100358

Sarah Aljelawy , Ehssan Al-Bermany , Ali Razzaq Abdulridha

Polymer-based graphene oxide nanocomposites represent an attractive class of materials due to their functional groups and wide range of applications in engineering and medicine. In this study, the interaction between nano-chitosan (CS) and graphene oxide (GO) nanosheets within polyvinylpyrrolidone (PVP) blended with polyacrylic acid (PAA) was investigated to fabricate two novel PVP–PAA–CS/GO nanocomposites. Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of strong interfacial interactions and distinct functional groups. At the same time, X-ray diffraction (XRD) revealed a transition from amorphous to semicrystalline behavior after the incorporation of nanomaterials. Optical microscopy revealed the fracture surface characteristics and the fine dispersion of the components. UV–Vis spectroscopy demonstrated improved optical properties. Furthermore, the optical absorbance at 340 nm increased from 0.65 in PVP–PAA to 1.09 in PVP–PAA–CS/GO, indicating that ternary mix polymers and GO nanoparticles have formed a complex at around 300 nm, with a reduction of the optical band gap from 3.7 to 3.4 eV. The addition of nanomaterials enhanced the absorption behavior, dielectric constants (real and imaginary), and optical conductivity. Furthermore, the radiation attenuation of the composites improved significantly, with the half-value layer (HVL) increasing from 2.41 to 4.13 cm. These results highlight the potential of the prepared nanocomposites for diverse optoelectronic and light-shielding applications.

聚合物基氧化石墨烯纳米复合材料由于其功能基团和在工程和医学上的广泛应用而成为一类有吸引力的材料。在本研究中，研究了纳米壳聚糖（CS）与氧化石墨烯（GO）纳米片在聚乙烯吡咯烷酮（PVP）与聚丙烯酸（PAA）共混中相互作用，制备了两种新型PVP - PAA - CS/GO纳米复合材料。傅里叶红外光谱（FTIR）证实存在强的界面相互作用和明显的官能团。同时，x射线衍射（XRD）结果表明，纳米材料掺入后，材料由非晶向半晶转变。光学显微镜显示了断口表面特征和组分的精细分散。紫外可见光谱显示了改进的光学性能。此外，PVP-PAA在340 nm处的光学吸光度从0.65增加到1.09，表明三元混合聚合物和氧化石墨烯纳米粒子在300 nm附近形成了配合物，光学带隙从3.7减小到3.4 eV。纳米材料的加入增强了材料的吸收性能、介电常数（实介电常数和虚介电常数）和导电性。此外，复合材料的辐射衰减显著提高，半值层（HVL）从2.41 cm增加到4.13 cm。这些结果突出了所制备的纳米复合材料在各种光电和光屏蔽应用方面的潜力。

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引用次数: 0

Deadly cures: Unlocking anticancer potential of reptile, amphibian, and arthropod venoms through molecular innovation and nanotechnology 致命治疗：通过分子创新和纳米技术释放爬行动物、两栖动物和节肢动物毒液的抗癌潜力

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.nxnano.2026.100378

Pranav Ragavendra Shankar , Apsara Unni

Venoms from reptiles, amphibians, and arthropods represent a rich source of bioactive molecules with promising anticancer potential. Recent studies have highlighted the selective cytotoxicity of venom components including snake phospholipase A2 enzymes, scorpion peptides (chlorotoxin), and frog derived antimicrobial peptides against cancer cells. These molecules exert multifaceted effects, such as inducing apoptosis, inhibiting metastasis, and modulating the tumor microenvironment, thereby impairing tumor growth and progression. Advances in nanotechnology based delivery systems and peptide engineering have significantly improved the stability, bioavailability, and specificity of venom derived agents, enhancing their safety and therapeutic efficacy. Preclinical investigations demonstrate potent anticancer activity across multiple tumor models, and early clinical studies suggest translational potential. Current research continues to explore the molecular mechanisms underlying venom-mediated cytotoxicity, while formulation strategies and regulatory considerations are being optimized to facilitate clinical development. Future directions include the design of synthetic venom analogs, AI assisted drug discovery, and personalized medicine approaches, which collectively aim to harness the full therapeutic potential of venom peptides. By integrating natural bioactivity with modern biomedical technologies, venom derived compounds are emerging as a novel and promising avenue in the development of next-generation oncological therapeutics. This review provides a comprehensive overview of venom diversity, anticancer mechanisms, recent advances in formulation and delivery, and the challenges and opportunities for translating venom-based agents into clinical practice.

来自爬行动物、两栖动物和节肢动物的毒液是具有抗癌潜力的生物活性分子的丰富来源。最近的研究强调了蛇毒成分的选择性细胞毒性，包括蛇磷脂酶A2酶、蝎子肽（氯毒素）和青蛙衍生的抗菌肽对癌细胞的作用。这些分子发挥多方面的作用，如诱导细胞凋亡、抑制转移、调节肿瘤微环境等，从而影响肿瘤的生长和进展。基于纳米技术的传递系统和肽工程的进步显著提高了毒液衍生剂的稳定性、生物利用度和特异性，增强了它们的安全性和治疗效果。临床前研究表明，在多种肿瘤模型中具有强大的抗癌活性，早期临床研究表明具有转化潜力。目前的研究继续探索毒液介导的细胞毒性的分子机制，同时正在优化配方策略和监管考虑，以促进临床发展。未来的方向包括设计合成毒液类似物、人工智能辅助药物发现和个性化医疗方法，这些方法的共同目标是利用毒液肽的全部治疗潜力。通过将天然生物活性与现代生物医学技术相结合，蛇毒衍生化合物正在成为开发下一代肿瘤治疗药物的一种新的和有前途的途径。本文综述了蛇毒的多样性、抗癌机制、制剂和递送的最新进展，以及将基于蛇毒的药物转化为临床实践的挑战和机遇。

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引用次数: 0

Sennoside-functionalized ZrO₂ nanoparticles via Cassia angustifolia: Gram-selective antibacterial and anticancer nanoplatform with green synthesis 以决明子为原料的senno苷功能化的ZrO 2纳米粒子：绿色合成的革兰氏选择性抗菌抗癌纳米平台

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-06 DOI: 10.1016/j.nxnano.2025.100330

Aarti Jathar , Samreen Fatema , Mazahar Farooqui , Abhay Dashrath , Dattatraya Jirekar , Pramila Ghumare

Sennoside-functionalized zirconium dioxide nanoparticles (Sen–ZrO₂ NPs) were engineered via a single-step green synthesis route using Cassia angustifolia leaf extract as both a bio reductant and stabilizer. Structural characterization confirmed phase-pure tetragonal ZrO₂ formation through X-ray diffraction (XRD), while Fourier-transform infrared spectroscopy (FTIR) verified sennoside anchoring via characteristic CO and O–H vibrations at 1680 cm⁻¹ and 3605 cm⁻¹. Scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS) revealed spherical morphologies with uniform elemental distribution. The Sen–ZrO₂ NPs exhibited pronounced Gram-selective antibacterial activity, demonstrating a fourfold potency enhancement against Staphylococcus aureus (MIC = 64 µg mL⁻¹) compared to unmodified ZrO₂. Time-kill assays further demonstrated a rapid 4-log reduction in bacterial viability within 6 h. Against MCF-7 breast cancer cells, the nanoparticles displayed dose-dependent cytotoxicity (IC₅₀ = 61.44 µg mL⁻¹), representing a 2.3-fold improvement over bare ZrO₂. This dual bioactivity is attributed to sennoside-mediated redox modulation and surface functionalization, which act synergistically to enhance membrane disruption and reactive oxygen species (ROS) generation. This work establishes a sustainable plant-engineered ZrO₂ nanoplatform with integrated antibacterial–anticancer functionality, presenting a viable green approach to advanced nanotherapeutics for combating antimicrobial resistance and cancer.

以决明子叶提取物为生物还原剂和稳定剂，通过一步绿色合成工艺制备了senno苷功能化二氧化锆纳米粒子（Sen-ZrO₂NPs）。结构表征通过x射线衍射（XRD）证实了相纯四方ZrO₂形成，而傅里叶变换红外光谱（FTIR）证实了sennoside通过1680 cm⁻¹ 和3605 cm⁻¹的特征CO和O-H振动锚定。扫描电子显微镜和能量色散x射线能谱分析（SEM/EDS）显示其呈球形，元素分布均匀。Sen-ZrO₂NPs表现出明显的革兰选择性抗菌活性，与未修饰的ZrO₂相比，对金黄色葡萄球菌（MIC = 64 µg mL⁻¹）的效力增强了四倍。时间杀伤试验进一步表明，细菌活力在6 h内迅速降低4对数。对MCF-7乳腺癌细胞，纳米颗粒显示出剂量依赖性的细胞毒性（IC₅₀= 61.44 µg mL⁻¹），比裸ZrO₂提高2.3倍。这种双重生物活性归因于sennoside介导的氧化还原调节和表面功能化，它们协同作用以增强膜破坏和活性氧（ROS）的产生。这项工作建立了一个具有综合抗菌抗癌功能的可持续植物工程ZrO 2纳米平台，为对抗抗生素耐药性和癌症的先进纳米治疗提供了可行的绿色途径。

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引用次数: 0

From pollution to solution: Optimized UiO-66 based metal-organic framework for environmental cleanup 从污染到解决：优化的UiO-66基金属有机框架，用于环境净化

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-10 DOI: 10.1016/j.nxnano.2025.100333

Azieyanti Nurain Azmin , Pua Fei Ling , Halina Misran

Metal-organic framework (MOF) is known as an advanced material with high surface area and porosity and emerging for environmental remediation. In this study, a sustainable zirconium-based MOF, known as UiO-66 was synthesized using zirconium oxynitrate as a chloride-less metal precursor and organic linker from recycled polyethylene terephthalate (rPET). Synthesis parameters were optimized via Response Surface Methodology (RSM), and achieved the maximum BET surface area of 755 m²/g. To evaluate for microplastic removal, the UiO-66 were incorporated into polyvinylidene fluoride (PVDF)-based mixed-matrix membranes (MMM). The properties and characterizations including X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), X-Ray Photoelectron Spectroscopy (XPS), Raman Spectroscopy, and Brunauer-Emmett-Teller (BET) surface analysis, confirmed the structure and composition of the materials. Filtration test demonstrated up to 105 ± 0.57 % removal efficiency against polymethylmethacrylate (PMMA), act as microplastic suspension. This work presents a sustainable approach to convert plastic waste into functional MOF and offer a green and effective strategy for environmental cleanup applications.

金属有机骨架（MOF）是一种具有高比表面积和高孔隙率的先进材料，在环境修复中崭露头角。本研究以再生聚对苯二甲酸乙二醇酯（rPET）为原料，以氧化锆为无氯金属前驱体和有机连接剂，合成了一种可持续的锆基MOF UiO-66。通过响应面法（RSM）对合成参数进行优化，得到最大BET表面积为755 m2/g。为了评估微塑料去除效果，将UiO-66掺入聚偏氟乙烯（PVDF）基混合基质膜（MMM）中。通过x射线衍射（XRD）、场发射扫描电子显微镜（FESEM）、x射线光电子能谱（XPS）、拉曼光谱（Raman）和布鲁诺尔-埃米特-泰勒（BET）表面分析等表征手段，证实了材料的结构和组成。过滤试验表明，对微塑料悬浮液聚甲基丙烯酸甲酯（PMMA）的去除率高达105 ± 0.57 %。本研究提出了一种将塑料垃圾转化为功能性MOF的可持续方法，并为环境清理应用提供了一种绿色有效的策略。

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引用次数: 0

Bioinformatics models in drug delivery: Predicting biomaterial-biological interactions for targeted therapies 药物传递中的生物信息学模型：预测靶向治疗的生物材料-生物相互作用

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-11 DOI: 10.1016/j.nxnano.2025.100335

Varshika Singh , Sukrat Sinha , Jaya Verma

The incorporation of bioinformatics into drug delivery research is revolutionizing the creation, development, and refinement of biomaterials utilized in therapeutic settings. Biomaterials, including nanomaterials, liposomes, and hydrogels, are essential components of drug delivery systems (DDS), as they enable controlled release, target specific tissues, and improve bioavailability. Nonetheless, grasping the interactions between these materials and biological systems poses a significant challenge. Increasingly, bioinformatics techniques such as molecular dynamics simulations, machine learning models, and docking analyses are being employed to forecast and enhance these interactions. These computational methods are vital for expediting the advancement of more effective and personalized drug delivery systems. This paper highlights the significance of bioinformatics in elucidating and predicting the interactions between biomaterials and biological systems, providing valuable perspectives on the future of drug delivery design.

生物信息学与药物传递研究的结合正在彻底改变治疗环境中使用的生物材料的创造、发展和改进。生物材料，包括纳米材料、脂质体和水凝胶，是药物传递系统（DDS）的重要组成部分，因为它们能够控制释放，靶向特定组织，并提高生物利用度。然而，掌握这些材料和生物系统之间的相互作用是一个重大的挑战。越来越多的生物信息学技术，如分子动力学模拟、机器学习模型和对接分析被用于预测和增强这些相互作用。这些计算方法对于加速更有效和个性化药物输送系统的发展至关重要。本文强调了生物信息学在阐明和预测生物材料与生物系统之间相互作用方面的重要性，为未来的药物传递设计提供了有价值的观点。

引用次数: 0

An overview of structural, optical, and magnetic properties of Mn-doped, Cu-doped, and (Mn, Cu)-codoped ZnS nanoparticles and its applications Mn掺杂、Cu掺杂和（Mn, Cu）共掺杂ZnS纳米粒子的结构、光学和磁性及其应用综述

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-23 DOI: 10.1016/j.nxnano.2025.100359

Pujarani Parida, Virendra Kumar Verma

Zinc Sulphide (ZnS) nanoparticles (NPs) are highly valued for their exceptional optical and magnetic properties, making them critical for applications in sensors, spintronics, and optoelectronic devices. This study explores the effects of Mn, Cu, and (Mn, Cu)-codoping on ZnS NPs prepared through wet chemical synthesis. It examines the variation of dopant concentrations that influence key characteristics such as crystalline size, band gap, and magnetic properties. The results show that Mn-doping widens the band gap from 3.32 eV to 4.51 eV, while Cu-doping further increases it from 2.97 eV to 4.99 eV, attributed to quantum confinement and the Burstein-Moss effect. Magnetically, pure and Cu-doped ZnS display ferromagnetism, whereas (Mn, Cu)-codoping leads to diminished ferromagnetic behavior due to reduced d⁰ magnetization. These improvements in band gap and magnetic properties highlight the potential of doped ZnS NPs for cutting-edge technological advancements.

硫化锌（ZnS）纳米颗粒（NPs）因其独特的光学和磁性而受到高度重视，这使得它们在传感器、自旋电子学和光电子器件中的应用至关重要。本研究探讨了Mn， Cu和（Mn, Cu）共掺杂对湿法化学合成的ZnS NPs的影响。它检查了影响关键特性的掺杂剂浓度的变化，如晶体尺寸、带隙和磁性能。结果表明，mn掺杂使带隙从3.32 eV扩大到4.51 eV， cu掺杂使带隙从2.97 eV进一步扩大到4.99 eV，这是由于量子约束和Burstein-Moss效应的作用。在磁性方面，纯ZnS和Cu掺杂ZnS表现出铁磁性，而（Mn, Cu）共掺杂由于磁化强度降低而导致铁磁性减弱。这些带隙和磁性能方面的改进突出了掺杂ZnS NPs在尖端技术进步方面的潜力。

引用次数: 0

DNA-functionalized superparamagnetic Fe₃O₄ nanoparticles: In Vitro antioxidant and anticancer assessment in MCF-7 cancer cells dna功能化超顺磁性Fe₃O₄纳米颗粒：MCF-7癌细胞的体外抗氧化和抗癌评价

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2026-01-21 DOI: 10.1016/j.nxnano.2026.100370

Pratikeswar Panda, Rajaram Mohapatra

Magnet-mediated gene therapy has emerged as a promising alternative to conventional viral-based genetic strategies, with superparamagnetic iron oxide nanoparticles (Fe₃O₄NPs) being widely explored as non-viral vectors. Despite their availability for certain transfection applications, their broader biomedical potential remains underutilized. Moreover, ethical concerns surrounding human DNA limit translational research, making fish DNA a viable substitute. This study aimed to synthesize DNA-coated Fe₃O₄ nanoparticles (DMn) and further develop a Metformin (MRN)-conjugating DNA–Fe₃O₄ nanoconjugate (MDMn), evaluating their structural features, antioxidant activity, and anticancer potential against MCF-7 breast cancer cells. The synthesized DMn exhibited quasi-spherical morphology (90.4 nm) with a Zeta-potential of –42.20 mV, ensuring colloidal stability. Superparamagnetism was confirmed by the absence of hysteresis. FTIR, FESEM, AFM, and XRD validated DNA coating and decreased crystallinity. Docking studies revealed strong binding between MRN and DNA-Fe₃O₄NPs. Drug release was accelerated from MDMn (109 ± 0.05 % in 8 h) compared to pure MRN (110 ± 0.47 % in 26 h). Biologically, MDMn exhibited notable antioxidant activity (32.41 ± 1.62 % DPPH scavenging) and pronounced, dose-dependent cytotoxicity against MCF-7 cells, achieving 85.47 ± 1.62 % inhibition at 24 h, with a calculated IC₅₀ value of 28.47 ± 1.59 μM. DNA-functionalized Fe₃O₄ nanoparticles, especially MRN-conjugate MDMn, represent a promising non-viral therapeutic platform with potential for targeted breast cancer treatment.

磁性介导的基因治疗已经成为传统的基于病毒的遗传策略的一种有希望的替代方案，超顺磁性氧化铁纳米颗粒（Fe₃O₄NPs）被广泛探索为非病毒载体。尽管它们可用于某些转染应用，但其更广泛的生物医学潜力仍未得到充分利用。此外，围绕人类DNA的伦理问题限制了转化研究，使鱼类DNA成为可行的替代品。该研究旨在合成dna包被的Fe₃O₄纳米颗粒（DMn），并进一步开发二甲双胍（MRN）偶联DNA-Fe₃O₄纳米偶联物（MDMn），评估其结构特征、抗氧化活性和对MCF-7乳腺癌细胞的抗癌潜力。合成的DMn具有准球形形貌（90.4 nm）， ζ电位为-42.20 mV，具有良好的胶体稳定性。超顺磁性通过不存在磁滞得到证实。FTIR， FESEM， AFM和XRD验证了DNA涂层的结晶度降低。对接研究显示MRN和DNA-Fe₃O₄NPs之间有很强的结合。与纯MRN（110 ± 0.47 %,26 h）相比，MDMn的药物释放速度加快（8 h内109 ± 0.05 %）。生物,MDMn表现出显著的抗氧化活性(32.41 ±1.62  % DPPH清除),明显存在剂量依赖的相关性对MCF-7细胞细胞毒性,达到85.47 ±1.62  %抑制24 h,以计算IC₅ ₀价值28.47±1.59  μM。dna功能化的Fe₃O₄纳米颗粒，特别是mrn偶联的MDMn，代表了一种有潜力的非病毒治疗平台，具有靶向治疗乳腺癌的潜力。

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引用次数: 0

Pigment mediated biosynthesis of crystalline silver nanostructures: Structural characterization and enhanced multifunctional bioactivity 色素介导的结晶银纳米结构的生物合成：结构表征和增强的多功能生物活性

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1016/j.nxnano.2026.100364

Akshay Chavan , Guruprasad Mavlankar , Prajakta Baikar , Parvindar Sah , Neha Mourya , Pravin Tirmali , Umesh Kakde

Harnessing the innate biochemical intelligence of nature is redefining nanotechnology. The present study reports the use of a red pigment from Talaromyces australis for the synthesis of AgNPs using sunlight. Color changes confirmed the formation of AgNPs, which was evidenced by the observation of a SPR peak at ∼ 430 nm. TEM revealed spherical AgNPs with an average size of 16 ± 2 nm, whereas NTA showed a narrow size distribution and excellent colloidal stability. The FCC structure was confirmed using XRD, and FTIR confirmed the involvement of three functional groups (hydroxyl, carbonyl, and C–O) in the reduction and stabilization of AgNPs. Disc diffusion assays indicated that the pigment inhibited the growth of Escherichia coli, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa, and Bacillus subtilis, and that the inhibition was concentration-dependent (zones: 9.33–15.66 mm). Antimicrobial activity was pronounced at a higher concentration of AgNPs (1 mg/mL), with zones of inhibition between 12.33–13.00 mm. MIC confirmed that antimicrobial activity was enhanced for the AgNPs (500 µg/mL for crude pigment and 62.5 µg/mL for AgNPs). Improvements were also observed in antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay (DPPH IC₅₀ < 10 µg/mL) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid assay (ABTS IC₅₀ < 10 µg/mL) and dose-dependent cytotoxicity (GI₅₀ = < 10 µg/mL and TGI = 53.0 µg/mL). These findings imply that Talaromyces australis pigment is a highly efficient and sustainable bio-reductant for the rapid biosynthesis of multifunctional AgNPs with improved biomedical potential.

利用大自然天生的生化智能正在重新定义纳米技术。本研究报告了使用来自南Talaromyces australis的红色色素利用阳光合成AgNPs。颜色变化证实了AgNPs的形成，这是在~ 430 nm处观察到的SPR峰所证明的。TEM显示AgNPs的平均粒径为16 ± 2 nm，而NTA显示AgNPs的粒径分布窄，胶体稳定性好。用XRD和FTIR证实了FCC的结构，并证实了三个官能团（羟基、羰基和C-O）参与了AgNPs的还原和稳定。圆盘扩散试验表明，该色素对大肠杆菌、金黄色葡萄球菌、伤寒沙门氏菌、铜绿假单胞菌和枯草芽孢杆菌的生长均有抑制作用，且抑制作用呈浓度依赖性（范围：9.33 ~ 15.66 mm）。AgNPs在较高浓度（1 mg/mL）下具有明显的抑菌活性，抑菌区在12.33 ~ 13.00 mm之间。MIC证实AgNPs的抗菌活性增强（粗色素500 µg/mL， AgNPs 62.5 µg/mL）。使用2,2-二苯基-1-吡啶酰肼（DPPH）测定法（DPPH IC₅₀< 10 µg/mL）和2,2 ' -氮基-双-(3-乙基苯并噻唑-6-磺酸测定法（ABTS IC₅₀< 10 µg/mL）和剂量依赖性细胞毒性（GI₅₀= <； 10 µg/mL和TGI = 53.0 µg/mL）也观察到抗氧化活性的改善。这些发现表明，南Talaromyces australis色素是一种高效、可持续的生物还原剂，可用于快速生物合成多功能AgNPs，具有更高的生物医学潜力。

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引用次数: 0

Quantum optics in photocatalytic hydrogen production: Light-matter interaction at the quantum scale 光催化制氢中的量子光学：量子尺度上的光-物质相互作用

Next Nanotechnology

Pub Date : 2026-06-01 Epub Date: 2025-12-16 DOI: 10.1016/j.nxnano.2025.100355

Sarah Susan Jolly , A.R. Twinkle , B.S. Arun Sasi , R. Reshma

Photocatalytic hydrogen production offers a sustainable path to clean energy, yet conventional approaches are limited by inefficiencies in light absorption and charge separation. This review explores how principles from quantum optics—such as coherence, entanglement, and nonclassical photon statistics—can fundamentally enhance photocatalytic processes. We delve into three key themes: (1) coherence-enhanced charge separation and exciton dynamics, (2) the impact of nonclassical light sources (e.g., squeezed and entangled photons) on catalytic efficiency, and (3) quantum optical control of light–matter interaction may offer new mechanisms for selective excitation, suppressed recombination, and low-intensity hydrogen evolution, though these remain largely theoretical or at proof-of-principle stages. Challenges in materials integration, decoherence management, and photonic engineering are critically examined. This review highlights a promising frontier in solar fuels research, where quantum light is not just a tool, but a resource for redefining the limits of photocatalytic efficiency.

光催化制氢为清洁能源提供了一条可持续的途径，但传统的方法受到光吸收和电荷分离效率低下的限制。这篇综述探讨了量子光学的原理——如相干、纠缠和非经典光子统计——如何从根本上增强光催化过程。我们深入研究了三个关键主题：(1)相干增强的电荷分离和激子动力学，(2)非经典光源（例如，压缩和纠缠光子）对催化效率的影响，以及(3)光-物质相互作用的量子光学控制可能为选择性激发，抑制重组和低强度氢演化提供新机制，尽管这些主要停留在理论或原理证明阶段。在材料集成，退相干管理和光子工程的挑战进行了严格审查。这篇综述强调了太阳能燃料研究的一个有前途的前沿，量子光不仅仅是一种工具，而是一种重新定义光催化效率极限的资源。

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引用次数: 0