HA-modified mesoporous Silica/hydroxyapatite hybrid targeted nanoparticles loaded with cabazitaxel and LY294002 for enhanced treatment of triple-negative breast cancer

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Letters Pub Date : 2024-07-02 DOI:10.1016/j.matlet.2024.136949

Songlin Liu , Xinzhe Shao , Hui Wang , Xinlei Chu , Wenjia Yang , Qingqiang Yao , Pingping Zhang

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Abstract

Hyaluronic acid-modified hydroxyapatite-doped mesoporous silica nanoparticle delivery system (CL@M/H-HA) co-delivering the chemotherapeutic agent cabazitaxel (CTX) and the targeted drug PI3K inhibitor LY294002, was constructed for the combination therapy of triple-negative breast cancer (TNBC). CTX and LY294002 had a synergistic effect on MDA-MB-231 cells and the two drugs could be released proportionally and synchronously from the CL@M/H-HA nanoparticles. The hydroxyapatite doped in CL@M/H-HA enabled the drug-carrying system to have a pH-responsive release property. In vitro cellular uptake experiments demonstrated that hyaluronic acid modified on the surface of nanoparticles favored the high uptake efficiency of nanoparticles by tumor cells MDA-MB-231, and nanoparticles co-loaded with CTX and LY294002 could induce more apoptosis of MDA-MB-231 cells. The fabricated dual-loaded targeted nanoparticles could improve the TNBC therapeutic efficacy, providing a promising combination therapy for TNBC.

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负载卡巴他赛和 LY294002 的 HA 改性介孔二氧化硅/羟基磷灰石混合靶向纳米粒子用于增强三阴性乳腺癌的治疗效果

研究人员构建了透明质酸修饰的羟基磷灰石掺杂介孔二氧化硅纳米颗粒递送系统（CL@M/H-HA），该系统可联合递送化疗药物卡巴他赛（CTX）和靶向药物PI3K抑制剂LY294002，用于三阴性乳腺癌（TNBC）的联合治疗。CTX和LY294002对MDA-MB-231细胞有协同作用，两种药物可从CL@M/H-HA纳米颗粒中按比例同步释放。CL@M/H-HA中掺杂的羟基磷灰石使载药系统具有pH响应释放特性。体外细胞摄取实验表明，纳米颗粒表面修饰的透明质酸有利于肿瘤细胞MDA-MB-231对纳米颗粒的高摄取效率，而共负载CTX和LY294002的纳米颗粒能诱导更多的MDA-MB-231细胞凋亡。所制备的双载体靶向纳米粒子可提高TNBC的疗效，为TNBC的联合治疗提供了可能。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive