Developmental pharmacology

IF 0.2 Q4 ANESTHESIOLOGY Anaesthesia and Intensive Care Medicine Pub Date : 2024-07-01 DOI:10.1016/j.mpaic.2024.05.004
Graeme Wilson
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Abstract

Growth and maturation characterize the transition of neonates to adults. The physiological changes that children undergo present numerous pharmacological conundrums for the anaesthetist. Extensive changes in drug absorption, protein binding, metabolism and excretion during development result in wide variability in drug disposition. Pharmacodynamic differences and genetic polymorphisms further exacerbate these pharmacokinetic disparities. These changes directly affect drug efficacy and toxicity, and an awareness of this is crucial for clinicians involved in paediatric anaesthesia. Population-based pharmacokinetic–pharmacodynamic modelling provides a novel prospect in paediatric pharmacology research. Modelling has the potential to improve safety in clinical trials and enhance our understanding of drug disposition in vulnerable populations like preterm neonates. Although progress is occurring in developmental pharmacology, gaps remain, and a lot yet remains to be elucidated.

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发育药理学
生长和成熟是新生儿向成人过渡的特征。儿童所经历的生理变化给麻醉师带来了许多药理学难题。在发育过程中,药物的吸收、蛋白结合、代谢和排泄发生了广泛的变化,导致药物的处置存在很大差异。药效学差异和基因多态性进一步加剧了这些药效学差异。这些变化直接影响到药物的疗效和毒性,因此了解这一点对于从事儿科麻醉的临床医生来说至关重要。基于人群的药代动力学-药效学建模为儿科药理学研究提供了新的前景。建模有可能提高临床试验的安全性,并加深我们对早产新生儿等易感人群药物处置的了解。尽管发育药理学正在取得进展,但差距依然存在,还有许多问题有待阐明。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
152
期刊介绍: Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.
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Editorial Board Contents Medical gases Spinal anaesthesia Premedication
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